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Number of items: 35.

Tisnerat, Camille, Di Ciano, Samuele, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 and Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 2025. Microwave-accelerated synthesis of novel triphosphate nucleoside prodrugs: Expanding the therapeutic arsenal of anticancer agents. Organic Letters 27 (1) , pp. 322-327. 10.1021/acs.orglett.4c04379
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Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Morozzi, Chiara, James, Edward, Renno, Giacomo, Cardano, Francesca and Fin, Andrea 2024. Fingolimod phosphoramidate prodrugs: Synthesis, photophysical characterisation and lipid bilayer interaction of fluorescent tagged Prodrug. Journal of Molecular Structure 1312 (2) , 138614. 10.1016/j.molstruc.2024.138614
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Gambrill, Benjamin, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Hughes, Stephen Fon, Shergill, Iqbal and Prokopovich, Polina ORCID: https://orcid.org/0000-0002-5700-9570 2024. Materials-based incidence of urinary catheter associated urinary tract infections and the causative micro-organisms: systematic review and meta-analysis. BMC Urology 24 (1) , 186. 10.1186/s12894-024-01565-x
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Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, di Ciano, Samule and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2024. Design, synthesis and biological evaluation of aryloxy thiophosphoramidate triesters of anticancer nucleoside analogues. Bioorganic and Medicinal Chemistry 103 , 117696. 10.1016/j.bmc.2024.117696
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Alghamdi, Raed, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 and Prokopovich, Polina ORCID: https://orcid.org/0000-0002-5700-9570 2024. Poly-beta-amino-ester licofelone conjugates development for osteoarthritis treatment †. RSC Advances 14 (1) , pp. 15-28. 10.1039/d3ra04967a
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Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Morozzi, Chiara, Novelli, Giulia, Giannantonio, Daniele, Duggan, Katrina, Vittorio, Serena, Fallis, Ian A. ORCID: https://orcid.org/0000-0001-7361-0182, De Luca, Laura and Williams, David ORCID: https://orcid.org/0000-0002-7351-5131 2023. Synthesis, molecular docking and antibacterial activity of an oxadiazole-based lipoteichoic acid inhibitor and its metabolites. Journal of Molecular Structure 1278 , 134977. 10.1016/j.molstruc.2023.134977
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Cook, Sophie R., Kirkham, Emily D., Best, Hannah, Waller-Evans, Helen ORCID: https://orcid.org/0000-0003-4133-6064, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 and Lloyd-Evans, Emyr ORCID: https://orcid.org/0000-0002-3626-1611 2023. Investigating lysosomal and cellular phenotypes of the lysosomal disorder cystinosis. Presented at: 19th Annual WORLDSymposium™ 2023, Orlando, Florida, 21-26 February 2023. Molecular Genetics and Metabolism. , vol.138 (2) Elsevier, p. 28. 10.1016/j.ymgme.2022.107061

Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 and Morewood, James 2022. Synthesis of 2‐Acetamido‐1,3,4‐Tri‐O‐Acetyl‐2‐Deoxy‐D‐Mannopyranose ‐6‐Phosphate Prodrugs as potential therapeutic agents. Current Protocols 2 (8) , e500. 10.1002/cpz1.500
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Vanden Avond, Mark A., Meng, Hui, Beatka, Margaret J., Helbling, Daniel C., Prom, Mariah J., Sutton, Jessica L., Slick, Rebecca A., Dimmock, David P., Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Pileggi, Elisa, Crutcher, Patrick, Thomas, Stephen and Lawlor, Michael W. 2021. The nucleotide prodrug CERC‐913 improves mtDNA content in primary hepatocytes from DGUOK‐deficient rats. Journal of Inherited Metabolic Disease 44 (2) , pp. 492-501. 10.1002/jimd.12354
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Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2021. An overview of ProTide technology and its implications to drug discovery. Expert Opinion on Drug Discovery 16 (10) , 1149--1161. 10.1080/17460441.2021.1922385
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Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Pileggi, Elisa, Richards, Jennifer, Wootton, Mandy, Van Leemputte, Thijs, Persoons, Leentje, De Coster, David, Villanueva, Xabier, Daelemans, Dirk, Steenackers, Hans, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 2020. Drug repurposing: phosphate prodrugs of anticancer and antiviral FDA-approved nucleosides as novel antimicrobials. Journal of Antimicrobial Chemotherapy 75 (10) , pp. 2864-2878. 10.1093/jac/dkaa268
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Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236 and McGuigan, Christopher 2019. A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer. European Journal of Medicinal Chemistry 180 , pp. 1-14. 10.1016/j.ejmech.2019.07.001
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Morozzi, Chiara, Sedláková, Jana, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Avigliano, Marialuce, Carbajo, Rosangela, Sandoval, Lucia, Valles-Ayoub, Yadira, Crutcher, Patrick, Thomas, Stephen and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2019. Targeting GNE myopathy: A dual prodrug approach for the delivery of N-acetylmannosamine 6-phosphate. Journal of Medicinal Chemistry 62 (17) , pp. 8178-8193. 10.1021/acs.jmedchem.9b00833
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Pileggi, Elisa, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2018. Preparation of pyrimidine alkenyl acyclic nucleoside phosphonoamidates. Current Protocols in Nucleic Acid Chemistry 74 (13-14) , e56. 10.1002/cpnc.56
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Pileggi, Elisa, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Andrei, Graciela, Schols, Dominique, Snoeck, Robert and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2018. Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs. Bioorganic and Medicinal Chemistry 26 (12) , pp. 3596-3609. 10.1016/j.bmc.2018.05.034
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Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2018. Phosphoramidates and phosphonamidates (ProTides) with antiviral activity. Antiviral Chemistry and Chemotherapy 26 , pp. 1-31. 10.1177/2040206618775243
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Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serafini, Sara, Albadry, Najmiyah, Snoeck, Robert and Andrei, Graciela 2017. Phosphonoamidate prodrugs of C5-substituted pyrimidine acyclic nucleosides for antiviral therapy. Antiviral Research 143 , pp. 262-268. 10.1016/j.antiviral.2017.04.013
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Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, De Biasi, Roberto, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190 and McGuigan, Christopher 2017. Synthetic approaches for the preparation of phosphoramidate prodrugs of 2’-deoxypseudoisocytidine. ChemistryOpen 6 (3) , pp. 424-436. 10.1002/open.201700019
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Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868, Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Giancotti, Gilda, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and McGuigan, Christopher 2017. Rational design and synthesis of novel phenylsulfonyl-benzamides as anti-prostate cancer agents. MedChemComm 8 (7) , pp. 1414-1420. 10.1039/C7MD00164A
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James, Edward, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2017. Kinase-independent phosphoramidate S1P1 receptor agonist benzyl ether derivatives. Biorganic and Medicinal Chemistry Letters 27 (6) , pp. 1371-1378. 10.1016/j.bmcl.2017.02.011
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Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Nutz, Eva, Kariuki, Benson ORCID: https://orcid.org/0000-0002-8658-3897 and Coogan, Michael P. 2017. Synthesis and substrate-controlled reactions of 2,2′-unsaturated biquinazolinones. Tetrahedron 73 (1) , pp. 55-63. 10.1016/j.tet.2016.11.060
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Marinozzi, Maura, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 and Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 2016. λ5-Phosphorus-Containing α-Diazo Compounds (PCDCs): a valuable tool for accessing phosphorus-functionalized molecules. Chemical Reviews 116 (22) , pp. 13991-14055. 10.1021/acs.chemrev.6b00373
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Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Ferrari, Valentina and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2016. Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? Journal of Medicinal Chemistry 59 (23) , pp. 10343-10382. 10.1021/acs.jmedchem.6b00325
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Bassetto, Marcella, Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Westwell, Andrew ORCID: https://orcid.org/0000-0002-5166-9236, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2016. Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer. European Journal of Medicinal Chemistry 118 , pp. 230-243. 10.1016/j.ejmech.2016.04.052
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Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Westwell, Andrew D. ORCID: https://orcid.org/0000-0002-5166-9236, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2016. Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety. Bioorganic and Medicinal Chemistry Letters 26 (15) , pp. 3636-3640. 10.1016/j.bmcl.2016.06.001
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McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190, Ferrari, Valentina ORCID: https://orcid.org/0000-0003-1895-8906, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Meneghesso, Silvia, Derudas, Marco, Farleigh, Laura, Zanetta, Paola and Bugert, Joachim ORCID: https://orcid.org/0000-0002-0556-3211 2016. Anti-flavivirus activity of different tritylated pyrimidine and purine nucleoside analogues. ChemistryOpen 5 (3) , pp. 227-235. 10.1002/open.201500216
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Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2015. Diastereoselective synthesis of P-chirogenic phosphoramidate prodrugs of nucleoside analogues (ProTides) via copper catalysed reaction. Chemical Communications 51 (38) , pp. 8070-8073. 10.1039/C5CC00448A
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Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 2015. Symmetrical diamidate prodrugs of nucleotide analogues for drug delivery. Current Protocols in Nucleic Acid Chemistry, Wiley-Blackwell, 60:15.6.1-15.6.10. (10.1002/0471142700.nc1506s60)
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Ferrari, Valentina ORCID: https://orcid.org/0000-0003-1895-8906, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2015. Chemoselective N-deacetylation of protected nucleosides and nucleotides promoted by the Schwartz's reagent. Nucleosides, Nucleotides & Nucleic Acids 34 (11) , pp. 799-814. 10.1080/15257770.2015.1075552
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Toti, Kiran S., Derudas, Marco, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Sinnaeve, Davy, Van den Broeck, Freya, Margamuljana, Lia, Martins, José C., Herdewijn, Piet, Balzarini, Jan, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Van Calenbergh, Serge 2014. Synthesis of an apionucleoside family and discovery of a prodrug with anti-HIV activity. Journal of Organic Chemistry 79 (11) , pp. 5097-5112. 10.1021/jo500659e
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Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Hinsinger, Karen, Flynn, Áine Sinéad, Powell, Ned George, Tristram, Amanda Jane, Balzarini, Jan and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2014. PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer. European Journal of Medicinal Chemistry 78 , pp. 259-268. 10.1016/j.ejmech.2014.03.051
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McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Derudas, Marco, Gonczy, Blanka, Hinsinger, Karen, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Snoeck, Robert, Andrei, Graciela, Balzarini, Jan, McHugh, Timothy D., Maitra, Arundhati, Akorli, Ernest, Evangelopoulos, Dimitrios and Bhakta, Sanjib 2014. ProTides of N-(3-(5-(2'-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents. Bioorganic and Medicinal Chemistry 22 (9) , pp. 2816-2824. 10.1016/j.bmc.2014.02.056
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McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Bourdin, Claire, Derudas, Marco, Hamon, Nadege, Hinsinger, Karen, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Madela, Karolina, Meneghesso, Silvia, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190, Chamberlain, Stanley, Kolykhalov, Alexander, Vernachio, John, Vanpouille, Christophe, Introini, Andrea, Margolis, Leonid and Balzarini, Jan 2013. Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides. European Journal of Medicinal Chemistry 70 , pp. 326-340. 10.1016/j.ejmech.2013.09.047
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Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2011. Medicinal chemistry of nucleoside phosphonate prodrugs for antiviral therapy. Antiviral Chemistry and Chemotherapy 22 (5) , pp. 181-203. 10.3851/IMP2012
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Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2007. Synthesis of atropisomeric 2,2'-disubstituted-3,3'-quinazolin-4,4'-diones and their application in asymmetric synthesis. PhD Thesis, Cardiff University.
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