p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis

Leal, Maria del Pilar Camacho, Sciortino, Marianna, Tornillo, Giusy, Colombo, Shana, Defilippi, Paola and Cabodi, Sara 2015. p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis. Gene 562 (1) , pp. 1-7. 10.1016/j.gene.2015.02.027

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Abstract

BCAR1 (also known as p130Cas/BCAR1) is an adaptor protein that belongs to the CAS family of scaffold proteins. In the past years, increasing evidence has demonstrated the ability of p130Cas/BCAR1 to activate signaling originating from mechanical stimuli, cell–extracellular matrix (ECM) adhesion and growth factor stimulation cascades during normal development and disease in various biological models. In this review we will specifically discuss the more recent data on the contribution of p130Cas/BCAR1 in the regulation of tissue homeostasis and its potential implications in pathological conditions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Subjects:	Q Science > QR Microbiology
Uncontrolled Keywords:	p130Cas/BCAR1; Intracellular signaling pathways; Development; Cancer; Adaptor protein; Cell motility
Publisher:	Elsevier
Date of Acceptance:	1 February 2015
Last Modified:	14 Mar 2019 16:00
URI:	https://orca.cardiff.ac.uk/id/eprint/75197

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