Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease

Bastide, Matthieu F., Meissner, Wassilios G., Picconi, Barbara, Fasano, Stefania ORCID: https://orcid.org/0000-0002-3696-7139, Fernagut, Pierre-Olivier, Feyder, Michael, Francardo, Veronica, Alcacer, Cristina, Ding, Yunmin, Brambilla, Riccardo ORCID: https://orcid.org/0000-0003-3569-5706, Fisone, Gilberto, Jon Stoessl, A., Bourdenx, Mathieu, Engeln, Michel, Navailles, Sylvia, De Deurwaerdère, Philippe, Ko, Wai Kin D., Simola, Nicola, Morelli, Micaela, Groc, Laurent, Rodriguez, Maria-Cruz, Gurevich, Eugenia V., Quik, Maryka, Morari, Michele, Mellone, Manuela, Gardoni, Fabrizio and Tronci, Elisabetta 2015. Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease. Progress in Neurobiology 132 , pp. 96-168. 10.1016/j.pneurobio.2015.07.002

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Abstract

Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately experienced by the vast majority of patients. In addition, psychiatric conditions often manifested as compulsive behaviours, are emerging as a serious problem in the management of L-dopa therapy. The present review attempts to provide an overview of our current understanding of dyskinesia and other L-dopa-induced dysfunctions, a field that dramatically evolved in the past twenty years. In view of the extensive literature on LID, there appeared a critical need to re-frame the concepts, to highlight the most suitable models, to review the central nervous system (CNS) circuitry that may be involved, and to propose a pathophysiological framework was timely and necessary. An updated review to clarify our understanding of LID and other L-dopa-related side effects was therefore timely and necessary. This review should help in the development of novel therapeutic strategies aimed at preventing the generation of dyskinetic symptoms.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Uncontrolled Keywords:	Parkinson's disease; Dyskinesia; L-dopa; Dopamine; Animal models; D1 receptor.
Publisher:	Elsevier
ISSN:	0301-0082
Date of Acceptance:	17 July 2015
Last Modified:	16 Nov 2022 07:47
URI:	https://orca.cardiff.ac.uk/id/eprint/76272

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