Bastide, Matthieu F., Meissner, Wassilios G., Picconi, Barbara, Fasano, Stefania ![]() ![]() |
Abstract
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately experienced by the vast majority of patients. In addition, psychiatric conditions often manifested as compulsive behaviours, are emerging as a serious problem in the management of L-dopa therapy. The present review attempts to provide an overview of our current understanding of dyskinesia and other L-dopa-induced dysfunctions, a field that dramatically evolved in the past twenty years. In view of the extensive literature on LID, there appeared a critical need to re-frame the concepts, to highlight the most suitable models, to review the central nervous system (CNS) circuitry that may be involved, and to propose a pathophysiological framework was timely and necessary. An updated review to clarify our understanding of LID and other L-dopa-related side effects was therefore timely and necessary. This review should help in the development of novel therapeutic strategies aimed at preventing the generation of dyskinetic symptoms.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Biosciences |
Uncontrolled Keywords: | Parkinson's disease; Dyskinesia; L-dopa; Dopamine; Animal models; D1 receptor. |
Publisher: | Elsevier |
ISSN: | 0301-0082 |
Date of Acceptance: | 17 July 2015 |
Last Modified: | 16 Nov 2022 07:47 |
URI: | https://orca.cardiff.ac.uk/id/eprint/76272 |
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