Genetic risk and age in Parkinson's disease: Continuum not stratum

Nalls, Mike A., Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Williams, Nigel Melvillle ORCID: https://orcid.org/0000-0003-1177-6931, Lubbe, Steven, Keller, Margaux F., Morris, Huw R. and Singleton, Andrew B. 2015. Genetic risk and age in Parkinson's disease: Continuum not stratum. Movement Disorders 30 (6) , pp. 850-854. 10.1002/mds.26192

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Abstract

BACKGROUND: Recent genomewide association study meta-analyses have identified 28 loci associated with risk of Parkinson's disease (PD). We sought to investigate whether these genetic risk factors are associated with PD age at onset. METHODS: Genetic risk scores from these loci were calculated for 6,249 cases. Linear regression tested associations between cumulative genetic risk and PD age at onset. RESULTS: Increasing genetic risk scores were associated with earlier age at onset (beta = -0.10, P = 2.92 × 10(-8) , adjusted r(2) = 0.27). Single standard deviation increase in genetic risk score is associated with 37.44 d earlier age at onset. Highest genetic risk was found at 31 to 60 y, onset slightly below average age at onset (AAO). CONCLUSIONS: Common genetic risk factors have a small but consistent association with AAO in PD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Advanced Research Computing @ Cardiff (ARCCA) MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Parkinson's disease; genetics; age at onset; statistics
Publisher:	Wiley
ISSN:	0885-3185
Date of Acceptance:	29 January 2015
Last Modified:	31 Oct 2022 09:23
URI:	https://orca.cardiff.ac.uk/id/eprint/80846

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