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Genetic risk and age in Parkinson's disease: Continuum not stratum

Nalls, Mike A., Escott-Price, Valentina ORCID:, Williams, Nigel Melvillle ORCID:, Lubbe, Steven, Keller, Margaux F., Morris, Huw R. and Singleton, Andrew B. 2015. Genetic risk and age in Parkinson's disease: Continuum not stratum. Movement Disorders 30 (6) , pp. 850-854. 10.1002/mds.26192

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BACKGROUND: Recent genomewide association study meta-analyses have identified 28 loci associated with risk of Parkinson's disease (PD). We sought to investigate whether these genetic risk factors are associated with PD age at onset. METHODS: Genetic risk scores from these loci were calculated for 6,249 cases. Linear regression tested associations between cumulative genetic risk and PD age at onset. RESULTS: Increasing genetic risk scores were associated with earlier age at onset (beta = -0.10, P = 2.92 × 10(-8) , adjusted r(2) = 0.27). Single standard deviation increase in genetic risk score is associated with 37.44 d earlier age at onset. Highest genetic risk was found at 31 to 60 y, onset slightly below average age at onset (AAO). CONCLUSIONS: Common genetic risk factors have a small but consistent association with AAO in PD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Advanced Research Computing @ Cardiff (ARCCA)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Parkinson's disease; genetics; age at onset; statistics
Publisher: Wiley
ISSN: 0885-3185
Date of Acceptance: 29 January 2015
Last Modified: 31 Oct 2022 09:23

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