Elevated expression of CD160 and 2B4 defines a cytolytic HIV-specific CD8+T-cell population in elite controllers

Pombo, Carolina, Wherry, E. John, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Betts, Michael R. 2015. Elevated expression of CD160 and 2B4 defines a cytolytic HIV-specific CD8+T-cell population in elite controllers. Journal of Infectious Diseases 212 (9) , pp. 1376-1386. 10.1093/infdis/jiv226

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Abstract

During chronic human immunodeficiency virus (HIV) infection, virus-specific CD8+ T cells become functionally exhausted. Unlike most chronically infected individuals, elite controllers of HIV retain CD8+ T-cell polyfunctionality and cytolytic capacity. It remains unclear whether elite controllers manifest T-cell exhaustion similar to subjects with chronic progression of HIV infection. Here we assessed coexpression of PD-1, Lag-3, CD160, and 2B4 as a measure of T-cell exhaustion in a cohort of elite controllers and in chronic progressors. We found that elite controllers have a high proportion of potentially exhausted (PD1+CD160+2B4+) HIV-specific CD8+ T cells that is comparable to the proportion in chronic progressors. However, elite controllers also harbor a population of HIV-specific CD160+2B4+ CD8+ T cells that correlates with cytolytic capacity, as measured by perforin expression, a population not commonly present in chronic progressors. We therefore propose that coexpression of CD160 and 2B4 delineates a population of cytolytic CD8+ T cells important for the control of HIV.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	HIV; elite controllers; T-cell exhaustion; PD-1; CD160; 2B4; CD8+ T cells
Publisher:	Oxford University Press
ISSN:	0022-1899
Date of Acceptance:	6 April 2015
Last Modified:	31 Oct 2022 10:24
URI:	https://orca.cardiff.ac.uk/id/eprint/84759

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