MR1 presentation of vitamin B-based metabolite ligands

McWilliam, Hamish EG, Birkinshaw, Richard W, Villadangos, Jose A, McCluskey, James and Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522 2015. MR1 presentation of vitamin B-based metabolite ligands. Current Opinion in Immunology 34 , pp. 28-34. 10.1016/j.coi.2014.12.004

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Abstract

The major histocompatibility complex class I-related molecule MR1 can bind a novel class of antigens, namely a family of related small organic vitamin B metabolites. When bound to MR1 these metabolites are presented to a population of innate-like T cells, mucosal-associated invariant T (MAIT) cells that express a semi-invariant T cell receptor (TCR). Several non-activating and activating MR1-restricted ligands have been described, which are the degradation products of, or intermediates of, vitamin B9 (folic acid) or vitamin B2 (riboflavin), respectively. The MAIT-activating intermediates of the riboflavin synthesis pathway are unique to a wide range of microbes, and accordingly represent a molecular signature of microbial infection. Recently insights into the binding of these vitamin B metabolites to MR1, and subsequent recognition by the MAIT TCR, have been gleaned, illustrating a novel antigen presentation system.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0952-7915
Last Modified:	31 Oct 2022 10:25
URI:	https://orca.cardiff.ac.uk/id/eprint/84815

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