McWilliam, Hamish EG, Birkinshaw, Richard W, Villadangos, Jose A, McCluskey, James and Rossjohn, Jamie  ORCID: https://orcid.org/0000-0002-2020-7522
2015.
MR1 presentation of vitamin B-based metabolite ligands.
Current Opinion in Immunology
34
, pp. 28-34.
10.1016/j.coi.2014.12.004
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Abstract
The major histocompatibility complex class I-related molecule MR1 can bind a novel class of antigens, namely a family of related small organic vitamin B metabolites. When bound to MR1 these metabolites are presented to a population of innate-like T cells, mucosal-associated invariant T (MAIT) cells that express a semi-invariant T cell receptor (TCR). Several non-activating and activating MR1-restricted ligands have been described, which are the degradation products of, or intermediates of, vitamin B9 (folic acid) or vitamin B2 (riboflavin), respectively. The MAIT-activating intermediates of the riboflavin synthesis pathway are unique to a wide range of microbes, and accordingly represent a molecular signature of microbial infection. Recently insights into the binding of these vitamin B metabolites to MR1, and subsequent recognition by the MAIT TCR, have been gleaned, illustrating a novel antigen presentation system.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | Elsevier |
| ISSN: | 0952-7915 |
| Last Modified: | 31 Oct 2022 10:25 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/84815 |
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