Birkinshaw, Richard W., Pellicci, Daniel G., Cheng, Tan-Yun, Keller, Andrew N., Sandoval-Romero, Maria, Gras, Stephanie, de Jong, Annemieke, Uldrich, Adam P., Moody, D. Branch, Godfrey, Dale I. and Rossjohn, Jamie  ORCID: https://orcid.org/0000-0002-2020-7522
2015.
αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands.
Nature Immunology
16
, pp. 258-266.
10.1038/ni.3098
|
Abstract
A central paradigm in αβ T cell–mediated immunity is the simultaneous co-recognition of antigens and antigen-presenting molecules by the αβ T cell antigen receptor (TCR). CD1a presents a broad repertoire of lipid-based antigens. We found that a prototypical autoreactive TCR bound CD1a when it was presenting a series of permissive endogenous ligands, while other lipid ligands were nonpermissive to TCR binding. The structures of two TCR-CD1a-lipid complexes showed that the TCR docked over the A′ roof of CD1a in a manner that precluded direct contact with permissive ligands. Nonpermissive ligands indirectly inhibited TCR binding by disrupting the TCR-CD1a contact zone. The exclusive recognition of CD1a by the TCR represents a previously unknown mechanism whereby αβ T cells indirectly sense self antigens that are bound to an antigen-presenting molecule.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | Nature Publishing Group |
| ISSN: | 1529-2908 |
| Date of Acceptance: | 6 January 2015 |
| Last Modified: | 31 Oct 2022 10:25 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/84816 |
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