Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control

Meltzer, Michael, Hasenbein, Sonja, Hauske, Patrick, Kucz, Nicolette, Merdanovic, Melisa, Grau, Sandra, Beil, Alexandra, Jones, Darran Dafydd ORCID: https://orcid.org/0000-0001-7709-3995, Krojer, Tobias, Clausen, Tim, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X and Kaiser, Markus 2008. Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control. Angewandte Chemie - International Edition 47 (7) , pp. 1332-1334. 10.1002/anie.200703273

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Abstract

Unleashing the proteolytic activity of DegP: A study with synthetic mimics of cellular stress signals reveals an allosteric (chemical) activation mechanism of the bacterial HtrA protease DegP, leading to a fine-tuned amplification of protein degradation during bacterial protein quality control (see scheme: binding of a peptide sequence (circles) increases activation. The nature of the penultimate residue (red) is shown to be decisive).

Item Type:	Article
Status:	Published
Schools:	Biosciences
Uncontrolled Keywords:	allosterism; proteases; protein quality control; proteins; stress signal
Publisher:	Wiley-Blackwell
ISSN:	1521-3773
Funders:	BBSRC
Last Modified:	17 Oct 2022 10:37
URI:	https://orca.cardiff.ac.uk/id/eprint/8755

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