Brachyury identifies a class of enteroendocrine cells in normal human intestinal crypts and colorectal cancer

Jezkova, Jana, Williams, J. S., Pinto, F., Sammut, Stephen, Williams, Geraint Trefor ORCID: https://orcid.org/0000-0003-3768-9940, Gollins, Simon, McFarlane, R. J., Reis, R. M. and Wakeman, J. A. 2016. Brachyury identifies a class of enteroendocrine cells in normal human intestinal crypts and colorectal cancer. Oncotarget 7 , pp. 11478-11486. 10.18632/oncotarget.7202

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Abstract

Normal homeostasis of adult intestinal epithelium and repair following tissue damage is maintained by a balance of stem and differentiated cells, many of which are still only poorly characterised. Enteroendocrine cells of the gut are a small population of differentiated, secretory cells that are critical for integrating nutrient sensing with metabolic responses, dispersed amongst other epithelial cells. Recent evidence suggests that sub-sets of secretory enteroendocrine cells can act as reserve stem cells. Given the link between cells with stem-like properties and cancer, it is important that we identify factors that might provide a bridge between the two. Here, we identify a sub-set of chromogranin A-positive enteroendocrine cells that are positive for the developmental and cancer-associated transcription factor Brachyury in normal human small intestinal and colonic crypts. Whilst chromogranin A-positive enteroendocrine cells are also Brachyury-positive in colorectal tumours, expression of Brachyury becomes more diffuse in these samples, suggesting a more widespread function in cancer. The finding of the developmental transcription factor Brachyury in normal adult human intestinal crypts may extend the functional complexity of enteroendocrine cells and serves as a platform for assessment of the molecular processes of intestinal homeostasis that underpins our understanding of human health, cancer and aging.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	Impact Journals LLC
ISSN:	1949-2553
Date of First Compliant Deposit:	22 April 2016
Date of Acceptance:	23 January 2016
Last Modified:	04 May 2023 19:08
URI:	https://orca.cardiff.ac.uk/id/eprint/89853

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