Jezkova, Jana, Williams, J. S., Pinto, F., Sammut, Stephen, Williams, Geraint Trefor  ORCID: https://orcid.org/0000-0003-3768-9940, Gollins, Simon, McFarlane, R. J., Reis, R. M. and Wakeman, J. A.
2016.
Brachyury identifies a class of enteroendocrine cells in normal human intestinal crypts and colorectal cancer.
Oncotarget
7
, pp. 11478-11486.
10.18632/oncotarget.7202
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Abstract
Normal homeostasis of adult intestinal epithelium and repair following tissue damage is maintained by a balance of stem and differentiated cells, many of which are still only poorly characterised. Enteroendocrine cells of the gut are a small population of differentiated, secretory cells that are critical for integrating nutrient sensing with metabolic responses, dispersed amongst other epithelial cells. Recent evidence suggests that sub-sets of secretory enteroendocrine cells can act as reserve stem cells. Given the link between cells with stem-like properties and cancer, it is important that we identify factors that might provide a bridge between the two. Here, we identify a sub-set of chromogranin A-positive enteroendocrine cells that are positive for the developmental and cancer-associated transcription factor Brachyury in normal human small intestinal and colonic crypts. Whilst chromogranin A-positive enteroendocrine cells are also Brachyury-positive in colorectal tumours, expression of Brachyury becomes more diffuse in these samples, suggesting a more widespread function in cancer. The finding of the developmental transcription factor Brachyury in normal adult human intestinal crypts may extend the functional complexity of enteroendocrine cells and serves as a platform for assessment of the molecular processes of intestinal homeostasis that underpins our understanding of human health, cancer and aging.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Medicine |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Publisher: | Impact Journals LLC |
| ISSN: | 1949-2553 |
| Date of First Compliant Deposit: | 22 April 2016 |
| Date of Acceptance: | 23 January 2016 |
| Last Modified: | 04 May 2023 19:08 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/89853 |
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