Hornsby, Amanda K. E., Redhead, Yushi T., Rees, Daniel J., Ratcliff, Michael S. G., Reichenbach, Alex, Wells, Timothy ![]() ![]() |
![]() |
PDF
- Published Version
Available under License Creative Commons Attribution. Download (4MB) |
Abstract
The beneficial effects of calorie restriction (CR) have been described at both organismal and cellular levels in multiple organs. However, our understanding of the causal mediators of such hormesis is poorly understood, particularly in the context of higher brain function. Here, we show that the receptor for the orexigenic hormone acyl-ghrelin, the growth hormone secretagogue receptor (Ghsr), is enriched in the neurogenic niche of the hippocampal dentate gyrus (DG). Acute elevation of acyl-ghrelin levels by injection or by overnight CR, increased DG levels of the neurogenic transcription factor, Egr-1. Two weeks of CR increased the subsequent number of mature newborn neurons in the DG of adult wild-type but not Ghsr−/− mice. CR wild-type mice also showed improved remote contextual fear memory. Our findings suggest that Ghsr mediates the beneficial effects of CR on enhancing adult hippocampal neurogenesis and memory.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Biosciences |
Additional Information: | This is an open access article under the terms of the CC-BY Attribution 4.0 International license. |
Publisher: | Elsevier |
ISSN: | 0306-4530 |
Date of First Compliant Deposit: | 7 April 2020 |
Date of Acceptance: | 20 September 2015 |
Last Modified: | 05 May 2023 11:33 |
URI: | https://orca.cardiff.ac.uk/id/eprint/90144 |
Citation Data
Cited 76 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
![]() |
Edit Item |