Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner

Hornsby, Amanda K. E., Redhead, Yushi T., Rees, Daniel J., Ratcliff, Michael S. G., Reichenbach, Alex, Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595, Francis, Lewis, Amstalden, Katia, Andrews, Zane B. and Davies, Jeffrey S. 2016. Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner. Psychoneuroendocrinology 63 , pp. 198-207. 10.1016/j.psyneuen.2015.09.023

[thumbnail of 1-s2.0-S0306453015009269-main.pdf] PDF - Published Version
Available under License Creative Commons Attribution.

Download (4MB)

Abstract

The beneficial effects of calorie restriction (CR) have been described at both organismal and cellular levels in multiple organs. However, our understanding of the causal mediators of such hormesis is poorly understood, particularly in the context of higher brain function. Here, we show that the receptor for the orexigenic hormone acyl-ghrelin, the growth hormone secretagogue receptor (Ghsr), is enriched in the neurogenic niche of the hippocampal dentate gyrus (DG). Acute elevation of acyl-ghrelin levels by injection or by overnight CR, increased DG levels of the neurogenic transcription factor, Egr-1. Two weeks of CR increased the subsequent number of mature newborn neurons in the DG of adult wild-type but not Ghsr−/− mice. CR wild-type mice also showed improved remote contextual fear memory. Our findings suggest that Ghsr mediates the beneficial effects of CR on enhancing adult hippocampal neurogenesis and memory.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Additional Information: This is an open access article under the terms of the CC-BY Attribution 4.0 International license.
Publisher: Elsevier
ISSN: 0306-4530
Date of First Compliant Deposit: 7 April 2020
Date of Acceptance: 20 September 2015
Last Modified: 05 May 2023 11:33
URI: https://orca.cardiff.ac.uk/id/eprint/90144

Citation Data

Cited 76 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics