Regulation of synthesis and roles of hyaluronan in peritoneal dialysis

Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435, Meran, Soma ORCID: https://orcid.org/0000-0003-3408-3978, Williams, Aled ORCID: https://orcid.org/0000-0002-6800-8135, Newbury, Lucy, Sauter, Matthias and Sitter, Thomas 2015. Regulation of synthesis and roles of hyaluronan in peritoneal dialysis. BioMed Research International 2015 , 427038. 10.1155/2015/427038

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Abstract

Hyaluronan (HA) is a ubiquitous extracellular matrix glycosaminoglycan composed of repeated disaccharide units of alternating D-glucuronic acid and D-N-acetylglucosamine residues linked via alternating β-1,4 and β-1,3 glycosidic bonds. HA is synthesized in humans by HA synthase (HAS) enzymes 1, 2, and 3, which are encoded by the corresponding HAS genes. Previous in vitro studies have shown characteristic changes in HAS expression and increased HA synthesis in response to wounding and proinflammatory cytokines in human peritoneal mesothelial cells. In addition, in vivo models and human peritoneal biopsy samples have provided evidence of changes in HA metabolism in the fibrosis that at present accompanies peritoneal dialysis treatment. This review discusses these published observations and how they might contribute to improvement in peritoneal dialysis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine
Subjects:	Q Science > Q Science (General)
Publisher:	Hindawi Publishing Corporation
Date of First Compliant Deposit:	13 May 2016
Date of Acceptance:	16 August 2015
Last Modified:	06 Jul 2023 17:10
URI:	https://orca.cardiff.ac.uk/id/eprint/90878

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