Responding to R-spondin: slit2 potentiates intestinal regeneration

Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916 and Sansom, Owen J. 2013. Responding to R-spondin: slit2 potentiates intestinal regeneration. Cell Stem Cell 13 , pp. 512-514. 10.1016/j.stem.2013.10.006

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Abstract

Gastrointestinal toxicity of chemoradiotherapy treatment in late-stage cancer patients limits tolerable doses and effectiveness of treatments. Zhou and colleagues in Nature ( Zhou et al., 2013) suggest that activating Robo/Slit signaling in concert with R-Spondin potentiates Wnt signaling in intestinal stem cells and drives successful intestinal regeneration and recovery.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Subjects:	Q Science > QH Natural history > QH426 Genetics
Publisher:	Elsevier
Date of First Compliant Deposit:	21 June 2016
Last Modified:	01 Jul 2023 07:42
URI:	https://orca.cardiff.ac.uk/id/eprint/91567

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