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Responding to R-spondin: slit2 potentiates intestinal regeneration

Phesse, Toby ORCID: and Sansom, Owen J. 2013. Responding to R-spondin: slit2 potentiates intestinal regeneration. Cell Stem Cell 13 , pp. 512-514. 10.1016/j.stem.2013.10.006

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Gastrointestinal toxicity of chemoradiotherapy treatment in late-stage cancer patients limits tolerable doses and effectiveness of treatments. Zhou and colleagues in Nature ( Zhou et al., 2013) suggest that activating Robo/Slit signaling in concert with R-Spondin potentiates Wnt signaling in intestinal stem cells and drives successful intestinal regeneration and recovery.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
European Cancer Stem Cell Research Institute (ECSCRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
Publisher: Elsevier
Date of First Compliant Deposit: 21 June 2016
Last Modified: 01 Jul 2023 07:42

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