3D culture of Her2+ breast cancer cells promotes AKT to MAPK switching and a loss of therapeutic response

Gangadhara, Sharath, Smith, Chris, Barrett-Lee, Peter and Hiscox, Stephen ORCID: https://orcid.org/0000-0003-0105-2702 2016. 3D culture of Her2+ breast cancer cells promotes AKT to MAPK switching and a loss of therapeutic response. BMC Cancer 16 (1) , 345. 10.1186/s12885-016-2377-z

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Abstract

The Her2 receptor is overexpressed in up to 25 % of breast cancers and is associated with a poor prognosis. Around half of Her2+ breast cancers also express the estrogen receptor and treatment for such tumours can involve both endocrine and Her2-targeted therapies. However, despite preclinical data supporting the effectiveness of these agents, responses can vary widely in the clinical setting. In light of the increasing evidence pointing to the interplay between the tumour and its extracellular microenvironment as a significant determinant of therapeutic sensitivity and response here we investigated the impact of 3D matrix culture of breast cancer cells on their therapeutic sensitivity.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology
Additional Information:	This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
Publisher:	BMC (part of Springer Nature)
ISSN:	1471-2407
Date of First Compliant Deposit:	11 June 2016
Date of Acceptance:	22 May 2016
Last Modified:	05 May 2023 12:36
URI:	https://orca.cardiff.ac.uk/id/eprint/91752

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