Cytokines: roles in atherosclerosis disease progression and potential therapeutic targets

Moss, Joe ORCID: https://orcid.org/0000-0002-1866-9752 and Ramji, Dipak Purshottam ORCID: https://orcid.org/0000-0002-6419-5578 2016. Cytokines: roles in atherosclerosis disease progression and potential therapeutic targets. Future Medicinal Chemistry 8 (11) , pp. 1317-1330. 10.4155/fmc-2016-0072

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Abstract

Atherosclerosis, the primary cause of cardiovascular disease (CVD), is a chronic inflammatory disorder in the walls of medium and large arteries. CVD is currently responsible for about one in three global deaths and this is expected to rise in the future due to an increase in the prevalence of obesity and diabetes. Current therapies for atherosclerosis mainly modulate lipid homeostasis and while successful at reducing the risk of a CVD-related death, they are associated with considerable residual risk and various side effects. There is, therefore, a need for alternative therapies aimed at regulating inflammation in order to reduce atherogenesis. This review will highlight the key role cytokines play during disease progression as well as potential therapeutic strategies to target them.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Future Science Ltd
ISSN:	1756-8919
Funders:	British Heart Foundation
Date of First Compliant Deposit:	6 April 2017
Date of Acceptance:	12 May 2016
Last Modified:	01 Nov 2022 10:38
URI:	https://orca.cardiff.ac.uk/id/eprint/92357

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