Post-learning hippocampal dynamics promote preferential retention of rewarding events

Gruber, Matthias ORCID: https://orcid.org/0000-0002-2754-0520, Ritchey, Maureen, Wang, Shao-Fang, Doss, Manoj K. and Ranganath, Charan 2016. Post-learning hippocampal dynamics promote preferential retention of rewarding events. Neuron 89 (5) , pp. 1110-1120. 10.1016/j.neuron.2016.01.017

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Abstract

Reward motivation is known to modulate memory encoding, and this effect depends on interactions between the substantia nigra/ventral tegmental area complex (SN/VTA) and the hippocampus. It is unknown, however, whether these interactions influence offline neural activity in the human brain that is thought to promote memory consolidation. Here we used fMRI to test the effect of reward motivation on post-learning neural dynamics and subsequent memory for objects that were learned in high- and low-reward motivation contexts. We found that post-learning increases in resting-state functional connectivity between the SN/VTA and hippocampus predicted preferential retention of objects that were learned in high-reward contexts. In addition, multivariate pattern classification revealed that hippocampal representations of high-reward contexts were preferentially reactivated during post-learning rest, and the number of hippocampal reactivations was predictive of preferential retention of items learned in high-reward contexts. These findings indicate that reward motivation alters offline post-learning dynamics between the SN/VTA and hippocampus, providing novel evidence for a potential mechanism by which reward could influence memory consolidation

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Publisher:	Elsevier (Cell Press)
ISSN:	0896-6273
Date of First Compliant Deposit:	22 November 2017
Date of Acceptance:	7 January 2016
Last Modified:	19 Nov 2024 04:00
URI:	https://orca.cardiff.ac.uk/id/eprint/96032

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