Tai, Ningwen, Peng, Jian, Liu, Fuqiang, Gulden, Elke, Hu, Youjia, Zhang, Xiaojun, Chen, Li, Wong, Florence Susan  ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li
2016.
Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice.
Journal of Experimental Medicine
213
(10)
, p. 2129.
10.1084/jem.20160526
|
Preview |
PDF
- Accepted Post-Print Version
Download (2MB) | Preview |
Abstract
Both animal model and human studies indicate that commensal bacteria may modify type 1 diabetes (T1D) development. However, the underlying mechanisms by which gut microbes could trigger or protect from diabetes are not fully understood, especially the interaction of commensal bacteria with pathogenic CD8 T cells. In this study, using islet-specific glucose-6-phosphatase catalytic subunit–related protein (IGRP)–reactive CD8 T cell receptor NY8.3 transgenic nonobese diabetic mice, we demonstrated that MyD88 strongly modulates CD8+ T cell–mediated T1D development via the gut microbiota. Some microbial protein peptides share significant homology with IGRP. Both the microbial peptide mimic of Fusobacteria and the bacteria directly activate IGRP-specific NY8.3 T cells and promote diabetes development. Thus, we provide evidence of molecular mimicry between microbial antigens and an islet autoantigen and a novel mechanism by which the diabetogenicity of CD8+ T cells can be regulated by innate immunity and the gut microbiota.
| Item Type: | Article |
|---|---|
| Date Type: | Published Online |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI) |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | Rockefeller University Press |
| ISSN: | 0022-1007 |
| Funders: | JDRF |
| Date of First Compliant Deposit: | 21 November 2016 |
| Date of Acceptance: | 5 August 2016 |
| Last Modified: | 05 May 2023 11:39 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/96317 |
Citation Data
Cited 77 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
 |
Edit Item |
Altmetric
Altmetric