Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications

Han, J., Schmidt, A., Zhang, T., Permentier, H., Groothuis, G. M. M., Bischoff, R., Kühn, F. E., Horvatovich, P. and Casini, A. ORCID: https://orcid.org/0000-0003-1599-9542 2017. Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications. Chemical Communications 53 (8) , pp. 1405-1408. 10.1039/C6CC08937B

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Abstract

Supramolecular Pd2L4 cages (L = ligand) hold promise as drug delivery systems. With the idea of achieving targeted delivery of the metallacages to tumor cells, the bioconjugation of exo-functionalized self-assembled Pd2L4 cages to peptides following two different approaches is reported for the first time. The obtained bioconjugates were analyzed and identified by high-resolution mass spectrometry.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Funders:	German Excellence Initiative and the European Union Seventh Framework Programme
Date of First Compliant Deposit:	11 January 2017
Date of Acceptance:	3 January 2017
Last Modified:	14 Nov 2024 15:30
URI:	https://orca.cardiff.ac.uk/id/eprint/97340

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