Synthesis and substrate-controlled reactions of 2,2′-unsaturated biquinazolinones

Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Nutz, Eva, Kariuki, Benson ORCID: https://orcid.org/0000-0002-8658-3897 and Coogan, Michael P. 2017. Synthesis and substrate-controlled reactions of 2,2′-unsaturated biquinazolinones. Tetrahedron 73 (1) , pp. 55-63. 10.1016/j.tet.2016.11.060

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Abstract

A series of BiQuinazolinones bearing either double or triple bonds in their lateral chains have been synthesized. These compounds were then subjected to substrate-controlled reactions such as Diels-Alder, epoxidation and Pauson-Khand reactions. The stereoselective outcome observed in these transformations is very promising for the future application of BiQuinazolinones as chiral auxiliaries.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords:	BiQuinazolinone; Atropisomers; Diastereoselectivity; Chiral induction
Publisher:	Elsevier
ISSN:	0040-4020
Date of First Compliant Deposit:	23 January 2017
Date of Acceptance:	21 November 2016
Last Modified:	18 Nov 2024 05:15
URI:	https://orca.cardiff.ac.uk/id/eprint/97657

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