Effect of conditioning on rat lung function measurements and implications for exposure and dose estimation of inhaled drugs

Paul, Graham, Gumbleton, Mark ORCID: https://orcid.org/0000-0002-7386-311X and Somers, Graham I 2017. Effect of conditioning on rat lung function measurements and implications for exposure and dose estimation of inhaled drugs. Inhalation

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Abstract

Although the latter equation is derived from measurements of MV in conscious animals of relevant species (mice, rats, beagle dogs and cynomolgus monkeys) used for non-clinical research, this approach overlooks physiological effects on lung function that can be induced by a substance’s properties. 3 Furthermore, MV measurements may vary due to differences in habituation of animals to procedures that also differ between species and protocols used by the 18 laboratories generating data used to derive Equation 2. eID = C × RMV × T BW

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	Q Science > QL Zoology Q Science > QR Microbiology R Medicine > RS Pharmacy and materia medica
Additional Information:	Copyright status: Upon publication of the article, Inhalation retains the copyright, which includes the right to use the article on our website, for promotional purposes, and for possible inclusion in an anthology. You must obtain Inhalation’s permission to post the article on your website or to make copies for distribution. You retain the right to prepare derivative works or to revise, adapt, or orally present your unedited article
Publisher:	CSC Publishing
ISSN:	1937-0717
Related URLs:	Publisher
Date of First Compliant Deposit:	6 February 2017
Date of Acceptance:	23 November 2016
Last Modified:	26 May 2023 16:37
URI:	https://orca.cardiff.ac.uk/id/eprint/98088

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