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Cas9 nickase-mediated contraction of CAG/CTG repeats in vivo is accompanied by improvements in Huntington's disease pathology.
Science Translational Medicine
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Bossi, Simon, Dhanasobhon, Dhanasak, Ellis-Davies, Graham C.R., Frontera, Jimena, Van Velze, Marcel de Brito, Lourenco, Joana, Murillo Bartolome, Alvaro ORCID: https://orcid.org/0000-0001-5470-9347, Lujan, Rafael, Casado, Mariano, Perez-Otano, Isabel, Bacci, Alberto, Popa, Daniela, Paoletti, Pierre and Rebola, Nelson
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GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits.
Neuron
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10.1016/j.neuron.2022.05.016
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Murillo Bartolome, Alvaro ORCID: https://orcid.org/0000-0001-5470-9347, Navarro, Ana I, Puelles, Eduardo, Zhang, Yajun, Petros, Timothy J and Pérez-Otaño, Isabel
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Temporal dynamics and neuronal specificity of Grin3a expression in the mouse forebrain.
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10.1093/cercor/bhaa330
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Marco, Sonia, Murillo Bartolome, Alvaro ORCID: https://orcid.org/0000-0001-5470-9347 and Pérez-Otaño, Isabel
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RNAi-based GluN3A silencing prevents and reverses disease phenotypes induced by mutant huntingtin.
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