Browse by Current Cardiff authors

Number of items: 13.

Lalaurie, C.J., Zhang, C., Liu, S.M., Bunting, K.A. and Dalby, P.A. 2024. An open source in silico workflow to assist in the design of fusion proteins. Computational Biology and Chemistry 113 , 108209. 10.1016/j.compbiolchem.2024.108209

Pandya, Akash, Zhang, Cheng, Barata, Teresa S., Brocchini, Steve, Howard, Mark J., Zloh, Mire and Dalby, Paul A. 2024. Molecular dynamics simulations reveal how competing protein-surface interactions for glycine, citrate, and water modulate stability in antibody fragment formulations. Molecular Pharmaceutics 21 (11) , 5497–5509. 10.1021/acs.molpharmaceut.4c00332

Tang, Jiazhi, Zhang, Cheng, Codina Castillo, Nuria, Lalaurie, Christophe J., Gao, Xin, Dalby, Paul A. and Kozielski, Frank 2023. Crystal structures and molecular dynamics simulations of a humanised antibody fragment at acidic to basic pH. Scientific Reports 13 (1) , 16281. 10.1038/s41598-023-42698-7

Zhang, Cheng, Berg, Adam, Joe, Carina C. D., Dalby, Paul A. and Douglas, Alexander D. 2023. Lyophilization to enable distribution of ChAdOx1 and ChAdOx2 adenovirus-vectored vaccines without refrigeration. npj Vaccines 8 (1) , 85. 10.1038/s41541-023-00674-2

Zhang, Cheng, Bye, Jordan W., Lui, Lok H., Zhang, Hongyu, Hales, John, Brocchini, Steve, Curtis, Robin A. and Dalby, Paul A. 2023. Enhanced Thermal Stability and Reduced Aggregation in an Antibody Fab Fragment at Elevated Concentrations. Molecular Pharmaceutics 20 (5) , pp. 2650-2661. 10.1021/acs.molpharmaceut.3c00081

Zhang, Cheng and Dalby, Paul Anthony 2022. Assessing and Engineering Antibody Stability Using Experimental and Computational Methods. Methods in Molecular Biology 2552 , pp. 165-197. 10.1007/978-1-0716-2609-2_9

Lee, Weiluo, Pradhan, Subhas, Zhang, Cheng, Venanzi, Niccolo A. E., Li, Weina, Goldrick, Stephen and Dalby, Paul A. 2022. Directed evolution for soluble and active periplasmic expression of bovine enterokinase in Escherichia coli. Scientific Reports 12 (1) , 17721. 10.1038/s41598-022-22574-6

Zhang, Cheng, Codina, Nuria, Tang, Jiazhi, Yu, Haoran, Chakroun, Nesrine, Kozielski, Frank and Dalby, Paul A. 2021. Comparison of the pH- and thermally-induced fluctuations of a therapeutic antibody Fab fragment by molecular dynamics simulation. Computational and Structural Biotechnology Journal 19 , pp. 2726-2741. 10.1016/j.csbj.2021.05.005

Zhang, Hongyu, Yang, Yang, Zhang, Cheng, Farid, Suzanne S. and Dalby, Paul A. 2021. Machine learning reveals hidden stability code in protein native fluorescence. Computational and Structural Biotechnology Journal 19 , 2750 - 2760. 10.1016/j.csbj.2021.04.047

Codina, Nuria, Hilton, David, Zhang, Cheng, Chakroun, Nesrine, Ahmad, Shahina S., Perkins, Stephen J. and Dalby, Paul A. 2019. An Expanded Conformation of an Antibody Fab Region by X-Ray Scattering, Molecular Dynamics, and smFRET Identifies an Aggregation Mechanism. Journal of Molecular Biology 431 (7) , pp. 1409-1425. 10.1016/j.jmb.2019.02.009

Zhang, Cheng, Samad, Maariyah, Yu, Haoran, Chakroun, Nesrine, Hilton, David and Dalby, Paul A. 2018. Computational Design To Reduce Conformational Flexibility and Aggregation Rates of an Antibody Fab Fragment. Molecular Pharmaceutics 15 (8) , pp. 3079-3092. 10.1021/acs.molpharmaceut.8b00186

Yu, Haoran, Yan, Yihan, Zhang, Cheng and Dalby, Paul A. 2017. Two strategies to engineer flexible loops for improved enzyme thermostability. Scientific Reports 7 (1) , 41212. 10.1038/srep41212

Barata, Teresa, Zhang, Cheng, Dalby, Paul, Brocchini, Steve and Zloh, Mire 2016. Identification of Protein–Excipient Interaction Hotspots Using Computational Approaches. International Journal of Molecular Sciences 17 (6) 10.3390/ijms17060853

This list was generated on Thu Jan 2 05:09:39 2025 GMT.