Richardson, Ciaran Joseph, Fielding, Ceri ORCID: https://orcid.org/0000-0002-5817-3153, Rowe, Martin and Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 2003. Epstein-Barr virus regulates STAT1 through latent membrane protein 1. Journal of Virology 77 (7) , pp. 4439-4443. 10.1128/JVI.77.7.4439-4443.2003 |
Abstract
This study shows a mechanism for the increase of signal transducer and activator of transcription 1 (STAT1) in Epstein-Barr virus-immortalized cells. Latent membrane protein 1 (LMP-1) expression was sufficient to induce STAT1 expression, DNA binding, and transcriptional activity. LMP-1-expressing cells can induce an increase in STAT1 expression in LMP-negative cells in the same culture, suggesting an indirect regulation of STAT1 expression. The increase in STAT1 expression is mediated by the C-terminal activating region 1 (CTAR-1) and/or CTAR-2 domains of LMP-1 and is inhibited by mutant IκB, demonstrating a role for NFκB in LMP-1-mediated STAT1 expression.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | Q Science > QR Microbiology > QR355 Virology |
Publisher: | American Society for Microbiology |
ISSN: | 0022-538X |
Last Modified: | 25 Oct 2022 09:05 |
URI: | https://orca.cardiff.ac.uk/id/eprint/57195 |
Citation Data
Cited 23 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
Edit Item |