Richardson, Ciaran Joseph, Fielding, Ceri ![]() ![]() |
Abstract
This study shows a mechanism for the increase of signal transducer and activator of transcription 1 (STAT1) in Epstein-Barr virus-immortalized cells. Latent membrane protein 1 (LMP-1) expression was sufficient to induce STAT1 expression, DNA binding, and transcriptional activity. LMP-1-expressing cells can induce an increase in STAT1 expression in LMP-negative cells in the same culture, suggesting an indirect regulation of STAT1 expression. The increase in STAT1 expression is mediated by the C-terminal activating region 1 (CTAR-1) and/or CTAR-2 domains of LMP-1 and is inhibited by mutant IκB, demonstrating a role for NFκB in LMP-1-mediated STAT1 expression.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | Q Science > QR Microbiology > QR355 Virology |
Publisher: | American Society for Microbiology |
ISSN: | 0022-538X |
Last Modified: | 25 Oct 2022 09:05 |
URI: | https://orca.cardiff.ac.uk/id/eprint/57195 |
Citation Data
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