Richardson, Ciaran Joseph, Fielding, Ceri  ORCID: https://orcid.org/0000-0002-5817-3153, Rowe, Martin and Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499
2003.
Epstein-Barr virus regulates STAT1 through latent membrane protein 1.
Journal of Virology
77
(7)
, pp. 4439-4443.
10.1128/JVI.77.7.4439-4443.2003
|
Abstract
This study shows a mechanism for the increase of signal transducer and activator of transcription 1 (STAT1) in Epstein-Barr virus-immortalized cells. Latent membrane protein 1 (LMP-1) expression was sufficient to induce STAT1 expression, DNA binding, and transcriptional activity. LMP-1-expressing cells can induce an increase in STAT1 expression in LMP-negative cells in the same culture, suggesting an indirect regulation of STAT1 expression. The increase in STAT1 expression is mediated by the C-terminal activating region 1 (CTAR-1) and/or CTAR-2 domains of LMP-1 and is inhibited by mutant IκB, demonstrating a role for NFκB in LMP-1-mediated STAT1 expression.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | Q Science > QR Microbiology > QR355 Virology |
| Publisher: | American Society for Microbiology |
| ISSN: | 0022-538X |
| Last Modified: | 25 Oct 2022 09:05 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/57195 |
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