Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 and Jenkins, Brendan J. 2018. Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer. Nature Reviews Immunology 18 , pp. 773-789. 10.1038/s41577-018-0066-7

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Abstract

The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM), leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) and cardiotrophin-like cytokine factor 1 (CLCF1). Membership of this cytokine family is defined by usage of common β-receptor signalling subunits, which activate various intracellular signalling pathways. Each IL-6 family member elicits responses essential to the physiological control of immune homeostasis, haematopoiesis, inflammation, development and metabolism. Accordingly, distortion of these cytokine activities often promotes chronic disease and cancer; the pathological importance of this is exemplified by the successful treatment of certain autoimmune conditions with drugs that target the IL-6 pathway. Here, we discuss the emerging roles for IL-6 family members in infection, chronic inflammation, autoimmunity and cancer and review therapeutic strategies designed to manipulate these cytokines in disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Nature Research
ISSN:	1474-1733
Date of First Compliant Deposit:	31 October 2018
Date of Acceptance:	25 September 2018
Last Modified:	05 Dec 2024 21:45
URI:	https://orca.cardiff.ac.uk/id/eprint/116367

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