Jones, Simon A.  ORCID: https://orcid.org/0000-0001-7297-9711 and Jenkins, Brendan J.
2018.
Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer.
Nature Reviews Immunology
18
, pp. 773-789.
10.1038/s41577-018-0066-7
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Abstract
The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM), leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) and cardiotrophin-like cytokine factor 1 (CLCF1). Membership of this cytokine family is defined by usage of common β-receptor signalling subunits, which activate various intracellular signalling pathways. Each IL-6 family member elicits responses essential to the physiological control of immune homeostasis, haematopoiesis, inflammation, development and metabolism. Accordingly, distortion of these cytokine activities often promotes chronic disease and cancer; the pathological importance of this is exemplified by the successful treatment of certain autoimmune conditions with drugs that target the IL-6 pathway. Here, we discuss the emerging roles for IL-6 family members in infection, chronic inflammation, autoimmunity and cancer and review therapeutic strategies designed to manipulate these cytokines in disease.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Publisher: | Nature Research |
| ISSN: | 1474-1733 |
| Date of First Compliant Deposit: | 31 October 2018 |
| Date of Acceptance: | 25 September 2018 |
| Last Modified: | 05 Dec 2024 21:45 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/116367 |
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