Modeling common Alzheimer’s disease with high and low polygenic risk in human iPSC: A large-scale research resource

Maguire, Emily, Winston, Jincy, Ellwood, Sarah, O'Donoghue, Rachel, Shaw, Bethany, Morales, Atahualpa, Keat, Samuel, Evans, Alexandra, Marshall, Rachel, Luckcuck, Lauren, Brown, Laura, Salis, Elisa, Leonenko, Ganna ORCID: https://orcid.org/0000-0001-8025-661X, Denning, Nicola, Allen, Nicholas ORCID: https://orcid.org/0000-0003-4009-186X, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Webber, Caleb ORCID: https://orcid.org/0000-0001-8063-7674, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Sims, Rebecca ORCID: https://orcid.org/0000-0002-3885-1199, Cowley, Sally A., Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259, Carpanini, Sarah M., Hall-Roberts, Hazel and EADB Consortium 2025. Modeling common Alzheimer’s disease with high and low polygenic risk in human iPSC: A large-scale research resource. Stem Cell Reports , 102570. 10.1016/j.stemcr.2025.102570

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Abstract

Common forms of Alzheimer’s disease (AD) are complex and polygenic. We have created a research resource that seeks to capture the extremes of polygenic risk in a collection of human induced pluripotent stem cell (iPSC) lines from over 100 donors: the IPMAR Resource (iPSC Platform to Model Alzheimer's Disease Risk). Donors were selected from a large UK cohort of 6,000+ research-diagnosed early or late-onset AD cases and elderly cognitively healthy controls, many of whom have lived through the age of risk for disease development (>85 years). We include iPSC with extremes of global AD polygenic risk (high-risk late-onset AD: 34; high-risk early-onset AD: 29; low-risk control: 27) as well as those reflecting complement pathway-specific genetic risk (high-risk AD: 9; low-risk controls: 10). All iPSC have associated clinical, longitudinal, and genetic datasets and will be available through collaboration or from cell (EBiSC) and data (DPUK) repositories.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Professional Services > Advanced Research Computing @ Cardiff (ARCCA) Schools > Biosciences Schools > Medicine
Publisher:	Cell Press
ISSN:	2213-6711
Date of First Compliant Deposit:	19 June 2025
Date of Acceptance:	5 June 2025
Last Modified:	17 Jul 2025 11:44
URI:	https://orca.cardiff.ac.uk/id/eprint/178829

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