Maguire, Emily, Winston, Jincy, Ellwood, Sarah, O'Donoghue, Rachel, Shaw, Bethany, Castillo Morales, Atahualpa, Keat, Samuel, Evans, Alexandra, Marshall, Rachel, Luckcuck, Lauren, Brown, Laura, Salis, Elisa, Leonenko, Ganna  ORCID: https://orcid.org/0000-0001-8025-661X, Denning, Nicola, Allen, Nicholas ORCID: https://orcid.org/0000-0003-4009-186X, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Webber, Caleb ORCID: https://orcid.org/0000-0001-8063-7674, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Sims, Rebecca ORCID: https://orcid.org/0000-0002-3885-1199, Cowley, Sally A., Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259, Carpanini, Sarah M., Hall-Roberts, Hazel and EADB Consortium
2025.
Modeling common Alzheimer’s disease with high and low polygenic risk in human iPSC: A large-scale research resource.
Stem Cell Reports
20
(8)
, 102570.
10.1016/j.stemcr.2025.102570
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Abstract
Common forms of Alzheimer’s disease (AD) are complex and polygenic. We have created a research resource that seeks to capture the extremes of polygenic risk in a collection of human induced pluripotent stem cell (iPSC) lines from over 100 donors: the IPMAR Resource (iPSC Platform to Model Alzheimer's Disease Risk). Donors were selected from a large UK cohort of 6,000+ research-diagnosed early or late-onset AD cases and elderly cognitively healthy controls, many of whom have lived through the age of risk for disease development (>85 years). We include iPSC with extremes of global AD polygenic risk (high-risk late-onset AD: 34; high-risk early-onset AD: 29; low-risk control: 27) as well as those reflecting complement pathway-specific genetic risk (high-risk AD: 9; low-risk controls: 10). All iPSC have associated clinical, longitudinal, and genetic datasets and will be available through collaboration or from cell (EBiSC) and data (DPUK) repositories.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Professional Services > Advanced Research Computing @ Cardiff (ARCCA) Schools > Biosciences Schools > Medicine |
| Publisher: | Cell Press |
| ISSN: | 2213-6711 |
| Date of First Compliant Deposit: | 19 June 2025 |
| Date of Acceptance: | 5 June 2025 |
| Last Modified: | 23 Sep 2025 12:47 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/178829 |
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