Davies, Luke Cynlais, Rosas, Marcela  ORCID: https://orcid.org/0000-0002-9442-9638, Jenkins, Stephen J., Liao, Chia-Te, Scurr, Martin John ORCID: https://orcid.org/0000-0002-4120-0688, Brombacher, Frank, Fraser, Donald James ORCID: https://orcid.org/0000-0003-0102-9342, Allen, Judith E., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421
2013.
Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation.
Nature Communications
4
, 1886.
10.1038/ncomms2877
|
Abstract
The general paradigm is that monocytes are recruited to sites of inflammation and terminally differentiate into macrophages. There has been no demonstration of proliferation of peripherally-derived inflammatory macrophages under physiological conditions. Here we show that proliferation of both bone marrow-derived inflammatory and tissue-resident macrophage lineage branches is a key feature of the inflammatory process with major implications for the mechanisms underlying recovery from inflammation. Both macrophage lineage branches are dependent on M-CSF during inflammation, and thus the potential for therapeutic interventions is marked. Furthermore, these observations are independent of Th2 immunity. These studies indicate that the proliferation of distinct macrophage populations provides a general mechanism for macrophage expansion at key stages during inflammation, and separate control mechanisms are implicated.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI) |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology |
| Publisher: | Nature Publishing Group |
| ISSN: | 2041-1723 |
| Last Modified: | 10 Nov 2023 12:44 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/48470 |
Citation Data
Cited 229 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
 |
Edit Item |
Dimensions
Dimensions