Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

Davies, Luke Cynlais, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Jenkins, Stephen J., Liao, Chia-Te, Scurr, Martin John ORCID: https://orcid.org/0000-0002-4120-0688, Brombacher, Frank, Fraser, Donald James ORCID: https://orcid.org/0000-0003-0102-9342, Allen, Judith E., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421 2013. Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nature Communications 4 , 1886. 10.1038/ncomms2877

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Abstract

The general paradigm is that monocytes are recruited to sites of inflammation and terminally differentiate into macrophages. There has been no demonstration of proliferation of peripherally-derived inflammatory macrophages under physiological conditions. Here we show that proliferation of both bone marrow-derived inflammatory and tissue-resident macrophage lineage branches is a key feature of the inflammatory process with major implications for the mechanisms underlying recovery from inflammation. Both macrophage lineage branches are dependent on M-CSF during inflammation, and thus the potential for therapeutic interventions is marked. Furthermore, these observations are independent of Th2 immunity. These studies indicate that the proliferation of distinct macrophage populations provides a general mechanism for macrophage expansion at key stages during inflammation, and separate control mechanisms are implicated.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Publisher:	Nature Publishing Group
ISSN:	2041-1723
Last Modified:	10 Nov 2023 12:44
URI:	https://orca.cardiff.ac.uk/id/eprint/48470

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