Inhibition of CREB activity in the dorsal portion of the striatum potentiates behavioral responses to drugs of abuse

Fasano, Stefania ORCID: https://orcid.org/0000-0002-3696-7139, Pittenger, Christopher and Brambilla, Riccardo ORCID: https://orcid.org/0000-0003-3569-5706 2009. Inhibition of CREB activity in the dorsal portion of the striatum potentiates behavioral responses to drugs of abuse. Frontiers in Behavioral Neuroscience 3 , 29. 10.3389/neuro.08.029.2009

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Abstract

The striatum participates in multiple forms of behavioral adaptation, including habit formation, other forms of procedural memory, and short- and long-term responses to drugs of abuse. The cyclic-AMP response element binding protein (CREB) family of transcription factors has been implicated in various forms of behavioral plasticity, but its role in the dorsal portion of the striatum-has been little explored. We previously showed that in transgenic mice in which CREB function is inhibited in the dorsal striatum, bidirectional synaptic plasticity and certain forms of long-term procedural memory are impaired. Here we show, in startling contrast, that inhibition of striatal CREB facilitates cocaine- and morphine-place conditioning and enhances locomotor sensitization to cocaine. These findings propose CREB as a positive regulator of dorsal striatum-dependent procedural learning but a negative regulator of drug-related learning.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Uncontrolled Keywords:	CREB; dorsal striatum; cocaine; morphine; locomotor sensitization; conditioned place preference
Publisher:	Frontiers Research Foundation
ISSN:	1662-5153
Date of First Compliant Deposit:	30 March 2016
Last Modified:	12 May 2023 16:40
URI:	https://orca.cardiff.ac.uk/id/eprint/48676

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