Fasano, Stefania  ORCID: https://orcid.org/0000-0002-3696-7139, Pittenger, Christopher and Brambilla, Riccardo ORCID: https://orcid.org/0000-0003-3569-5706
2009.
Inhibition of CREB activity in the dorsal portion of the striatum potentiates behavioral responses to drugs of abuse.
Frontiers in Behavioral Neuroscience
3
, 29.
10.3389/neuro.08.029.2009
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Abstract
The striatum participates in multiple forms of behavioral adaptation, including habit formation, other forms of procedural memory, and short- and long-term responses to drugs of abuse. The cyclic-AMP response element binding protein (CREB) family of transcription factors has been implicated in various forms of behavioral plasticity, but its role in the dorsal portion of the striatum-has been little explored. We previously showed that in transgenic mice in which CREB function is inhibited in the dorsal striatum, bidirectional synaptic plasticity and certain forms of long-term procedural memory are impaired. Here we show, in startling contrast, that inhibition of striatal CREB facilitates cocaine- and morphine-place conditioning and enhances locomotor sensitization to cocaine. These findings propose CREB as a positive regulator of dorsal striatum-dependent procedural learning but a negative regulator of drug-related learning.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Biosciences |
| Uncontrolled Keywords: | CREB; dorsal striatum; cocaine; morphine; locomotor sensitization; conditioned place preference |
| Publisher: | Frontiers Research Foundation |
| ISSN: | 1662-5153 |
| Date of First Compliant Deposit: | 30 March 2016 |
| Last Modified: | 10 Jul 2024 19:14 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/48676 |
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