BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells

Mart, Robert J. ORCID: https://orcid.org/0000-0003-2196-5840, Errington, Rachel Jane ORCID: https://orcid.org/0000-0002-8016-4376, Watkins, Catherine Louise, Chappell, Sally Claire, Wiltshire, Marie, Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905, Smith, Paul James and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2013. BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells. Molecular BioSystems 9 (11) , pp. 2597-2603. 10.1039/c3mb70246d

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Abstract

Dynamic physical interactions between proteins underpin all key cellular processes and are a highly attractive area for the development of research tools and medicines. Protein–protein interactions frequently involve α-helical structures, but peptides matching the sequences of these structures usually do not fold correctly in isolation. Therefore, much research has focused on the creation of small peptides that adopt stable α-helical structures even in the absence of their intended protein targets. We show that short peptides alkylated with azobenzene crosslinkers can be used to photo-stimulate mitochondrial membrane depolarization and cytochrome c release in permeabilised cells, the initial events of the intrinsic apoptosis pathway.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff Catalysis Institute (CCI) Chemistry Medicine Pharmacy
Subjects:	Q Science > QD Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	1742-206X
Funders:	BBSRC, EPSRC
Date of First Compliant Deposit:	30 March 2016
Last Modified:	17 Nov 2023 02:08
URI:	https://orca.cardiff.ac.uk/id/eprint/53558

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