Davey, Martin S., Willcox, Carrie R., Joyce, Stephen P., Ladell, Kristin  ORCID: https://orcid.org/0000-0002-9856-2938, Kasatskaya, Sofya A., McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Hunter, Stuart, Salim, Mahboob, Mohammed, Fiyaz, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Chudakov, Dmitriy M. and Willcox, Benjamin E.
2017.
Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance.
Nature Communications
8
, 14760.
10.1038/ncomms14760
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Abstract
γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2neg T cells, implicated in responses to viral infection and cancer. The prevalent Vδ1 T cell receptor (TCR) repertoire is private and initially unfocused in cord blood, typically becoming strongly focused on a few high-frequency clonotypes by adulthood. Clonal expansions have differentiated from a naive to effector phenotype associated with CD27 downregulation, retaining proliferative capacity and TCR sensitivity, displaying increased cytotoxic markers and altered homing capabilities, and remaining relatively stable over time. Contrastingly, Vδ2+ T cells express semi-invariant TCRs, which are present at birth and shared between individuals. Human Vδ1+ T cells have therefore evolved a distinct biology from the Vδ2+ subset, involving a central, personalized role for the γδ TCR in directing a highly adaptive yet unconventional form of immune surveillance.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Additional Information: | This work is licensed under a Creative Commons Attribution 4.0 International License. |
| Publisher: | Nature Research |
| ISSN: | 2041-1723 |
| Date of First Compliant Deposit: | 26 May 2017 |
| Date of Acceptance: | 30 January 2016 |
| Last Modified: | 16 Nov 2024 05:00 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/100895 |
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