FXR regulates intestinal stem cells response to bile acids in a high fat diet

Parry, Lee ORCID: https://orcid.org/0000-0002-4467-9196 and Phesse, Toby J ORCID: https://orcid.org/0000-0001-9568-4916 2019. FXR regulates intestinal stem cells response to bile acids in a high fat diet. Biotarget 3 (12) 10.21037/biotarget.2019.07.01

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Abstract

Although a high fat diet (HFD) is known to be associated with a poor clinical outcome for colorectal cancer (CRC) patients, the precise mechanisms underlying this are poorly understood. Fu and colleagues have recently identified high levels of bile acid (BA) in a preclinical mouse model of colon cancer, and that a HFD increases BA further which in turn promotes proliferation in Lgr5+ stem cells, via inhibition of farnesoid X receptor (FXR), to drive tumour progression (1).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Publisher:	AME Publishing Company
ISSN:	2522-669X
Date of First Compliant Deposit:	10 July 2019
Date of Acceptance:	30 June 2019
Last Modified:	30 Nov 2024 08:30
URI:	https://orca.cardiff.ac.uk/id/eprint/124140

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