Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes

Nödling, Alexander, Mills, Emily M., Li, Xuefei, Cardella, Davide, Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, Wu, Shih-Hsiung, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 and Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 2020. Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes. Chemical Communications 56 (34) , pp. 4672-4675. 10.1039/C9CC07931A

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Abstract

Organelle-specific delivery systems are of significant clinical interest. We demonstrate the use of common cyanine dyes Cy3 and Cy5 as vectors for targeting and delivering cargoes to mitochondria in cancer cells. Specifically, conjugation to the dyes can increase cytotoxicity by up to 1000-fold.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Funders:	EPSRC, Wellcome Trust
Date of First Compliant Deposit:	26 March 2020
Date of Acceptance:	20 February 2020
Last Modified:	06 Jan 2024 04:33
URI:	https://orca.cardiff.ac.uk/id/eprint/130592

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