Selective hydroboration - oxidation of terminal alkenes under flow conditions

Elsherbini, Mohamed, Huynh, Florence, Dunbabin, Alice, Allemann, Rudolf ORCID: https://orcid.org/0000-0002-1323-8830 and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2020. Selective hydroboration - oxidation of terminal alkenes under flow conditions. Chemistry - A European Journal 26 (50) , pp. 11423-11425. 10.1002/chem.202001650

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Abstract

Abstract An efficient flow process for the selective hydroboration and oxidation of different alkenes using 9‐BBN allows facile conversion in high productivity (1.4 g/h) of amorpha‐4,11‐diene to the corresponding alcohol, which is an advanced intermediate in the synthesis of the antimalarial drug artemisinin. The in situ reaction of borane and 1,5‐cyclooctadiene using a simple flow generator proved to be a cost efficient solution for the generation of 9‐BBN.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Wiley
ISSN:	0947-6539
Funders:	Bills and Melinda Gates Foundation
Date of First Compliant Deposit:	16 June 2020
Date of Acceptance:	22 April 2020
Last Modified:	24 Feb 2024 10:37
URI:	https://orca.cardiff.ac.uk/id/eprint/132477

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