Exact group sequential designs for two-arm experiments with Poisson distributed outcome variables

Grayling, Michael J., Wason, James M. S. and Mander, Adrian P. ORCID: https://orcid.org/0000-0002-0742-9040 2019. Exact group sequential designs for two-arm experiments with Poisson distributed outcome variables. Communications in Statistics - Theory and Methods 50 (1) , pp. 18-34. 10.1080/03610926.2019.1628273

PDF - Published Version Available under License Creative Commons Attribution. Download (1MB)

Abstract

We describe and compare two methods for the group sequential design of two-arm experiments with Poisson distributed data, which are based on a normal approximation and exact calculations respectively. A framework to determine near-optimal stopping boundaries is also presented. Using this framework, for a considered example, we demonstrate that a group sequential design could reduce the expected sample size under the null hypothesis by as much as 44% compared to a fixed sample approach. We conclude with a discussion of the advantages and disadvantages of the two presented procedures.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Centre for Trials Research (CNTRR)
Publisher:	Taylor & Francis
ISSN:	0361-0926
Date of First Compliant Deposit:	29 April 2021
Date of Acceptance:	31 May 2019
Last Modified:	05 May 2023 16:47
URI:	https://orca.cardiff.ac.uk/id/eprint/140821

Citation Data

Cited 1 time in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item