Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach

Lauder, Sarah N., Vanhaesebroeck, Bart and Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 2021. Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach. British Journal of Cancer 125 , pp. 467-469. 10.1038/s41416-021-01285-1

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Abstract

Emerging studies have demonstrated the potential of PI3Kδ blockade as an immunotherapy for solid tumours. In pre-clinical models, we recently demonstrated that anti-LAG3 immune checkpoint blockade vastly potentiated PI3Kδ-based immunotherapy, enabling successful tumour control in all treated mice.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	This article is licensed under a Creative Commons Attribution 4.0 International License
Publisher:	Springer Nature [academic journals on nature.com]
ISSN:	0007-0920
Date of First Compliant Deposit:	11 June 2021
Date of Acceptance:	21 January 2021
Last Modified:	05 May 2023 02:06
URI:	https://orca.cardiff.ac.uk/id/eprint/141855

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