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Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach

Lauder, Sarah N., Vanhaesebroeck, Bart and Gallimore, Awen 2021. Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach. British Journal of Cancer 125 , pp. 467-469. 10.1038/s41416-021-01285-1

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Abstract

Emerging studies have demonstrated the potential of PI3Kδ blockade as an immunotherapy for solid tumours. In pre-clinical models, we recently demonstrated that anti-LAG3 immune checkpoint blockade vastly potentiated PI3Kδ-based immunotherapy, enabling successful tumour control in all treated mice.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: This article is licensed under a Creative Commons Attribution 4.0 International License
Publisher: Springer Nature [academic journals on nature.com]
ISSN: 0007-0920
Date of First Compliant Deposit: 11 June 2021
Date of Acceptance: 21 January 2021
Last Modified: 09 Sep 2021 12:56
URI: https://orca.cardiff.ac.uk/id/eprint/141855

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