Unravelling the broader complexity of IL-6 involvement in health and disease

Jenkins, Robert H. ORCID: https://orcid.org/0000-0001-8500-9044, Hughes, Stuart T.O., Cardus Figueras, Ana and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 2021. Unravelling the broader complexity of IL-6 involvement in health and disease. Cytokine 148 , 155684. 10.1016/j.cyto.2021.155684

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Abstract

The classification of interleukin-6 (IL-6) as a pro-inflammatory cytokine undervalues the biological impact of this cytokine in health and disease. With broad activities affecting the immune system, tissue homeostasis and metabolic processes, IL-6 displays complex biology. The significance of these involvements has become increasingly important in clinical settings where IL-6 is identified as a prominent target for therapy. Here, clinical experience with IL-6 antagonists emphasises the need to understand the context-dependent properties of IL-6 within an inflammatory environment and the anticipated or unexpected consequences of IL-6 blockade. In this review, we will describe the immunobiology of IL-6 and explore the gamut of IL-6 bioactivity affecting the clinical response to biological drugs targeting this cytokine pathway.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Publisher:	Elsevier
ISSN:	1043-4666
Date of First Compliant Deposit:	2 September 2021
Date of Acceptance:	4 August 2021
Last Modified:	06 Nov 2023 21:23
URI:	https://orca.cardiff.ac.uk/id/eprint/143841

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