Jenkins, Robert H.  ORCID: https://orcid.org/0000-0001-8500-9044, Hughes, Stuart T.O., Cardus Figueras, Ana and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711
2021.
Unravelling the broader complexity of IL-6 involvement in health and disease.
Cytokine
148
, 155684.
10.1016/j.cyto.2021.155684
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Abstract
The classification of interleukin-6 (IL-6) as a pro-inflammatory cytokine undervalues the biological impact of this cytokine in health and disease. With broad activities affecting the immune system, tissue homeostasis and metabolic processes, IL-6 displays complex biology. The significance of these involvements has become increasingly important in clinical settings where IL-6 is identified as a prominent target for therapy. Here, clinical experience with IL-6 antagonists emphasises the need to understand the context-dependent properties of IL-6 within an inflammatory environment and the anticipated or unexpected consequences of IL-6 blockade. In this review, we will describe the immunobiology of IL-6 and explore the gamut of IL-6 bioactivity affecting the clinical response to biological drugs targeting this cytokine pathway.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI) |
| Publisher: | Elsevier |
| ISSN: | 1043-4666 |
| Date of First Compliant Deposit: | 2 September 2021 |
| Date of Acceptance: | 4 August 2021 |
| Last Modified: | 02 Dec 2024 13:45 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/143841 |
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