Jenkins, Robert H., Hughes, Stuart T.O., Cardus Figueras, Ana and Jones, Simon A.
2021.
Unravelling the broader complexity of IL-6 involvement in health and disease.
Cytokine
148
, 155684.
10.1016/j.cyto.2021.155684
Item availability restricted. |
![]() |
PDF
- Accepted Post-Print Version
Restricted to Repository staff only until 16 August 2022 due to copyright restrictions. Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (760kB) |
Abstract
The classification of interleukin-6 (IL-6) as a pro-inflammatory cytokine undervalues the biological impact of this cytokine in health and disease. With broad activities affecting the immune system, tissue homeostasis and metabolic processes, IL-6 displays complex biology. The significance of these involvements has become increasingly important in clinical settings where IL-6 is identified as a prominent target for therapy. Here, clinical experience with IL-6 antagonists emphasises the need to understand the context-dependent properties of IL-6 within an inflammatory environment and the anticipated or unexpected consequences of IL-6 blockade. In this review, we will describe the immunobiology of IL-6 and explore the gamut of IL-6 bioactivity affecting the clinical response to biological drugs targeting this cytokine pathway.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Medicine Systems Immunity Research Institute (SIURI) |
Publisher: | Elsevier |
ISSN: | 1043-4666 |
Date of First Compliant Deposit: | 2 September 2021 |
Date of Acceptance: | 4 August 2021 |
Last Modified: | 26 Oct 2021 16:36 |
URI: | https://orca.cardiff.ac.uk/id/eprint/143841 |
Citation Data
Cited 2 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
![]() |
Edit Item |