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Unravelling the broader complexity of IL-6 involvement in health and disease

Jenkins, Robert H. ORCID:, Hughes, Stuart T.O., Cardus Figueras, Ana and Jones, Simon A. ORCID: 2021. Unravelling the broader complexity of IL-6 involvement in health and disease. Cytokine 148 , 155684. 10.1016/j.cyto.2021.155684

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The classification of interleukin-6 (IL-6) as a pro-inflammatory cytokine undervalues the biological impact of this cytokine in health and disease. With broad activities affecting the immune system, tissue homeostasis and metabolic processes, IL-6 displays complex biology. The significance of these involvements has become increasingly important in clinical settings where IL-6 is identified as a prominent target for therapy. Here, clinical experience with IL-6 antagonists emphasises the need to understand the context-dependent properties of IL-6 within an inflammatory environment and the anticipated or unexpected consequences of IL-6 blockade. In this review, we will describe the immunobiology of IL-6 and explore the gamut of IL-6 bioactivity affecting the clinical response to biological drugs targeting this cytokine pathway.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Publisher: Elsevier
ISSN: 1043-4666
Date of First Compliant Deposit: 2 September 2021
Date of Acceptance: 4 August 2021
Last Modified: 06 Nov 2023 21:23

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