Use of a novel peptide welding technology platform for the development of B- and T-Cell epitope-based vaccines

Nicoli, Francesco, Pacifico, Salvatore, Gallerani, Eleonora, Marzola, Erika, Albanese, Valentina, Finessi, Valentina, Llewellyn-Lacey, Sian, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Appay, Victor, Marconi, Peggy, Guerrini, Remo, Caputo, Antonella and Gavioli, Riccardo 2021. Use of a novel peptide welding technology platform for the development of B- and T-Cell epitope-based vaccines. Vaccines 9 (5) , 526. 10.3390/vaccines9050526

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Abstract

Peptide vaccines incorporating B- and T-cell epitopes have shown promise in the context of various cancers and infections. These vaccines are relatively simple to manufacture, but more immunogenic formulations are considered a priority. We developed tetrabranched derivatives for this purpose based on a novel peptide welding technology (PWT). PWTs provide molecular scaffolds for the efficient synthesis of ultrapure peptide dendrimers, which allow the delivery of multiple ligands within a single macromolecular structure. Peptide vaccines incorporating T-cell epitopes derived from melanoma and B-cell epitopes derived from human immunodeficiency virus, synthesized using this approach, elicited primary immune responses in vitro and in vivo. Subcutaneous administration of the B-cell epitope-based vaccines also elicited more potent humoral responses than subcutaneous administration of the corresponding peptides alone. Highly immunogenic peptide epitope-based vaccines can therefore be generated quickly and easily using a novel PWT.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Centre for Law and Religion (CLR)
Publisher:	MDPI
ISSN:	2076-393X
Date of First Compliant Deposit:	9 February 2022
Date of Acceptance:	14 May 2021
Last Modified:	15 May 2023 21:13
URI:	https://orca.cardiff.ac.uk/id/eprint/147356

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