Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Use of a novel peptide welding technology platform for the development of B- and T-Cell epitope-based vaccines

Nicoli, Francesco, Pacifico, Salvatore, Gallerani, Eleonora, Marzola, Erika, Albanese, Valentina, Finessi, Valentina, Llewellyn-Lacey, Sian, Price, David A., Appay, Victor, Marconi, Peggy, Guerrini, Remo, Caputo, Antonella and Gavioli, Riccardo 2021. Use of a novel peptide welding technology platform for the development of B- and T-Cell epitope-based vaccines. Vaccines 9 (5) , 526. 10.3390/vaccines9050526

[thumbnail of Use of a novel peptide welding.pdf]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (4MB) | Preview

Abstract

Peptide vaccines incorporating B- and T-cell epitopes have shown promise in the context of various cancers and infections. These vaccines are relatively simple to manufacture, but more immunogenic formulations are considered a priority. We developed tetrabranched derivatives for this purpose based on a novel peptide welding technology (PWT). PWTs provide molecular scaffolds for the efficient synthesis of ultrapure peptide dendrimers, which allow the delivery of multiple ligands within a single macromolecular structure. Peptide vaccines incorporating T-cell epitopes derived from melanoma and B-cell epitopes derived from human immunodeficiency virus, synthesized using this approach, elicited primary immune responses in vitro and in vivo. Subcutaneous administration of the B-cell epitope-based vaccines also elicited more potent humoral responses than subcutaneous administration of the corresponding peptides alone. Highly immunogenic peptide epitope-based vaccines can therefore be generated quickly and easily using a novel PWT.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Centre for Law and Religion (CLR)
Publisher: MDPI
ISSN: 2076-393X
Date of First Compliant Deposit: 9 February 2022
Date of Acceptance: 14 May 2021
Last Modified: 22 Feb 2022 12:03
URI: https://orca.cardiff.ac.uk/id/eprint/147356

Citation Data

Cited 1 time in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics