Campion, Suzanne L., Brenna, Elena, Thomson, Elaine, Fischer, Will, Ladell, Kristin ![]() ![]() ![]() ![]() |
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Abstract
Naive and memory CD4+ T cells reactive with human immunodeficiency virus type 1 (HIV-1) are detectable in unexposed, unimmunized individuals. The contribution of preexisting CD4+ T cells to a primary immune response was investigated in 20 HIV-1–seronegative volunteers vaccinated with an HIV-1 envelope (Env) plasmid DNA prime and recombinant modified vaccinia virus Ankara (MVA) boost in the HVTN 106 vaccine trial (clinicaltrials.gov NCT02296541). Prevaccination naive or memory CD4+ T cell responses directed against peptide epitopes in Env were identified in 14 individuals. After priming with DNA, 40% (8/20) of the elicited responses matched epitopes detected in the corresponding preimmunization memory repertoires, and clonotypes were shared before and after vaccination in 2 representative volunteers. In contrast, there were no shared epitope specificities between the preimmunization memory compartment and responses detected after boosting with recombinant MVA expressing a heterologous Env. Preexisting memory CD4+ T cells therefore shape the early immune response to vaccination with a previously unencountered HIV-1 antigen.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Additional Information: | This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License |
Publisher: | American Society for Clinical Investigation |
ISSN: | 1558-8238 |
Date of First Compliant Deposit: | 23 May 2022 |
Date of Acceptance: | 7 October 2021 |
Last Modified: | 08 May 2023 02:32 |
URI: | https://orca.cardiff.ac.uk/id/eprint/149831 |
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