Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope

Dolton, Garry, Rius, Cristina, Hasan, Md Samiul, Wall, Aaron, Szomolay, Barbara ORCID:, Behiry, Enas, Whalley, Thomas, Southgate, Joel, Fuller, Anna, Morin, Théo, Topley, Katie, Tan, Li Rong, Goulder, Philip J.R., Spiller, Owen B. ORCID:, Rizkallah, Pierre J. ORCID:, Jones, Lucy C. ORCID:, Connor, Thomas R. ORCID: and Sewell, Andrew K. ORCID: 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185 (16) , pp. 2936-2951. 10.1016/j.cell.2022.07.002

[thumbnail of cell1-s2.0-S0092867422008492-main.pdf]
PDF - Published Version
Available under License Creative Commons Attribution.

Download (10MB) | Preview


We studied the prevalent cytotoxic CD8 T cell response mounted against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein269-277 epitope (sequence YLQPRTFLL) via the most frequent human leukocyte antigen (HLA) class I worldwide, HLA A∗02. The Spike P272L mutation that has arisen in at least 112 different SARS-CoV-2 lineages to date, including in lineages classified as “variants of concern,” was not recognized by the large CD8 T cell response seen across cohorts of HLA A∗02+ convalescent patients and individuals vaccinated against SARS-CoV-2, despite these responses comprising of over 175 different individual T cell receptors. Viral escape at prevalent T cell epitopes restricted by high frequency HLAs may be particularly problematic when vaccine immunity is focused on a single protein such as SARS-CoV-2 Spike, providing a strong argument for inclusion of multiple viral proteins in next generation vaccines and highlighting the need for monitoring T cell escape in new SARS-CoV-2 variants.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: This is an open access article under the CC BY license (
Publisher: Elsevier
ISSN: 0092-8674
Funders: Wellcome Trust
Date of First Compliant Deposit: 15 August 2022
Date of Acceptance: 7 July 2022
Last Modified: 30 May 2024 12:20

Citation Data

Cited 18 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics