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Number of items: 58.

Schmidlin, Thierry, Behiry, Enas, Thomas, Hannah, Dolton, Garry, Marino, Fabio, Hasan, Samar, von Essen, Magdalena, Gathungu, Rose M., Steigenberger, Barbara A., Selvadurai, Hayden, Dukes, Joseph, Brennan, Paul E., Spiller, Owen B. ORCID: https://orcid.org/0000-0002-9117-6911, Silk, Jonathan D., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Ternette, Nicola 2025. MR1-ligand cross-linking identifies vitamin B6 metabolites as TCR-reactive antigens. Cell Reports Methods , 101120. 10.1016/j.crmeth.2025.101120
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Dolton, Garry, Bulek, Anna, Wall, Aaron, Thomas, Hannah, Hopkins, Jade R, Rius, Cristina, Galloway, Sarah A.E., Whalley, Thomas, Tan, Li Rong, Morin, Theo, Omidvar, Nader, Fuller, Anna, Topley, Katie, Hasan, Samiul, Jain, Shika, D’Souza, Nirupa, Hodges-Hoyland, Tom, Spiller, Owen B. ORCID: https://orcid.org/0000-0002-9117-6911, Kronenberg-Versteeg, Deborah, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, van den Berg, Hugo A., Jones, Lucy C. ORCID: https://orcid.org/0000-0002-3872-4376, Peakman, Mark, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2024. HLA A*24:02-restricted T-cell receptors cross recognise bacterial and preproinsulin peptides in type 1 diabetes. Journal of Clinical Investigation 134 (18) , e164535. 10.1172/JCI164535
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Dolton, Garry, Rius, Cristina, Wall, Aaron, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Bianchi, Valentina, Galloway, Sarah A.E., Hasan, MD Samiul, Morin, Theo, Caillaud, Marine, Thomas, Hannah L., Theaker, Sarah, Tan, Li Rong, Fuller, Anna, Topley, Katie, Legut, Mateusz, Attaf, Merriem, Hopkins, Jade R., Behiry, Enas, Zabkiewicz, Joanna ORCID: https://orcid.org/0000-0003-0951-3825, Alvares, Caroline ORCID: https://orcid.org/0000-0003-4391-9802, Lloyd, Angharad, Rogers, Amber, Henley, Peter, Fegan, Chris ORCID: https://orcid.org/0000-0001-9685-0621, Ottmann, Oliver ORCID: https://orcid.org/0000-0001-9559-1330, Man, Stephen ORCID: https://orcid.org/0000-0001-9103-1686, Crowther, Michael D., Donia, Marco, Svane, Inge Marie, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Brown, Paul E., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2023. Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy. Cell 186 (16) , pp. 3333-3349. 10.1016/j.cell.2023.06.020
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Goncharov, Mikhail, Bagaev, Dmitry, Shcherbinin, Dmitrii, Zvyagin, Ivan, Bolotin, Dmitry, Thomas, Paul G., Minervina, Anastasia A., Pogorelyy, Mikhail V., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Nguyen, Thi H. O., Rowntree, Louise C., Clemens, E. Bridie, Kedzierska, Katherine, Dolton, Garry, Rius Rafael, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135, Samir, Jerome, Luciani, Fabio, Zornikova, Ksenia V., Khmelevskaya, Alexandra A., Sheetikov, Saveliy A., Efimov, Grigory A., Chudakov, Dmitry and Shugay, Mikhail 2022. VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2. Nature Methods 19 (9) , 1017–1019. 10.1038/s41592-022-01578-0

Dolton, Garry, Rius, Cristina, Hasan, Md Samiul, Wall, Aaron, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Behiry, Enas, Whalley, Thomas, Southgate, Joel, Fuller, Anna, Morin, Théo, Topley, Katie, Tan, Li Rong, Goulder, Philip J.R., Spiller, Owen B. ORCID: https://orcid.org/0000-0002-9117-6911, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Jones, Lucy C. ORCID: https://orcid.org/0000-0002-3872-4376, Connor, Thomas R. ORCID: https://orcid.org/0000-0003-2394-6504 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185 (16) , pp. 2936-2951. 10.1016/j.cell.2022.07.002
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Martini, Veronica, Paudyal, Basu, Chrun, Tiphany, McNee, Adam, Edmans, Matthew, Atangana Maze, Emmanuel, Clark, Beckie, Nunez, Alejandro, Dolton, Garry, Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135, Beverley, Peter, MacLoughlin, Ronan, Townsend, Alain and Tchilian, Elma 2021. Simultaneous aerosol and intramuscular immunization with influenza vaccine induces powerful protective local T cell and systemic antibody immune responses in pigs. Journal of Immunology 206 (2) , ji2001086. 10.4049/jimmunol.2001086
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Attaf, Meriem, Roider, Julia, Malik, Amna, Rius Rafael, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Dolton, Garry, Predergast, Andrew J., Leslie, Alasdair, Ndung'u, Thumbi, Kløverpris, Henrik N., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Goulder, Philip J. 2020. Cytomegalovirus-mediated T cell receptor repertoire perturbation is present in early life. Frontiers in Immunology 11 , 1587. 10.3389/fimmu.2020.01587
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Greenshields-Watson, Alexander, Attaf, Meriem, MacLachlan, Bruce J., Whalley, Thomas, Rius, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Wall, Aaron, Lloyd, Angharad, Hughes, Hywel, Strange, Kathryn E., Mason, Georgina H., Schauenburg, Andrea J., Hulin-Curtis, Sarah L. ORCID: https://orcid.org/0000-0003-0889-964X, Geary, James, Chen, Yuan, Lauder, Sarah N., Smart, Kathryn, Vijaykrishna, Dhanasekaran, Grau, Miguel L., Shugay, Mikhail, Andrews, Robert, Dolton, Garry, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Gallimore, Awen M. ORCID: https://orcid.org/0000-0001-6675-7004, Godkin, Andrew J. ORCID: https://orcid.org/0000-0002-1910-7567, Sewell, Andrew J. ORCID: https://orcid.org/0000-0003-3194-3135 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32 (2) , 107885. 10.1016/j.celrep.2020.107885
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Yeo, L., Pujol-Autonell, I., Baptista, R., Eichmann, M., Kronenberg-Versteeg, D., Heck, S., Dolton, G., Sewell, A. K. ORCID: https://orcid.org/0000-0003-3194-3135, Härkönen, T., Mikk, M.L., Toppari, J., Veijola, R., Knip, M., Ilonen, J. and Peakman, M. 2020. Circulating β cell‐specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes. Clinical and Experimental Immunology 199 (3) , pp. 263-277. 10.1111/cei.13391
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Crowther, Michael D., Dolton, Garry, Legut, Mateusz, Caillaud, Marine E., Lloyd, Angharad, Attaf, Meriem, Galloway, Sarah A. E., Rius, Cristina, Farrell, Colin P., Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Parker, Alan L. ORCID: https://orcid.org/0000-0002-9302-1761, Fuller, Anna, Donia, Marco, McCluskey, James, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Svane, Inge Marie, Phillips, John D. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2020. Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Nature Immunology 21 , 178 - 185. 10.1038/s41590-019-0578-8
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Whalley, Thomas, Dolton, Garry, Brown, Paul E., Wall, Aaron, Wooldridge, Linda, van den Berg, Hugo, Fuller, Anna, Hopkins, Jade R., Crowther, Michael D., Attaf, Meriem, Knight, Robin R., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Peakman, Mark, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533 2020. GPU-accelerated discovery of pathogen-derived molecular mimics of a T-cell insulin epitope. Frontiers in Immunology 11 , 296. 10.3389/fimmu.2020.00296
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Bagaev, Dmitry V, Vroomans, Renske M A, Samir, Jerome, Stervbo, Ulrik, Rius, Cristina, Dolton, Garry, Greenshields Watson, Alexander, Attaf, Meriem, Egorov, Evgeny S, Zvyagin, Ivan V, Babel, Nina, Cole, David K ORCID: https://orcid.org/0000-0003-0028-9396, Godkin, Andrew J ORCID: https://orcid.org/0000-0002-1910-7567, Sewell, Andrew K ORCID: https://orcid.org/0000-0003-3194-3135, Kesmir, Can, Chudakov, Dmitriy M, Luciani, Fabio and Shugay, Mikhail 2020. VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium. Nucleic Acids Research 48 (D1) , D1057-D1062. 10.1093/nar/gkz874
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MacLachlan, Bruce J., Dolton, Garry, Papakyriakou, Athanasios, Greenshields-Watson, Alexander, Mason, Georgina H., Schauenburg, Andrea, Besneux, Matthieu, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Elliott, Tim, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 2019. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. Journal of Biological Chemistry 294 (52) , pp. 20246-20258. 10.1074/jbc.RA119.009437
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Mohammed, Rebar N., Wehenkel, Sophie C., Galkina, Elena V., Yates, Emma-Kate, Preece, Graham, Newman, Andrew, Watson, H. Angharad, Ohme, Julia, Bridgeman, John S., Durairaj, Ruban R. P., Moon, Owen R., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L., Dolton, Garry, Troeberg, Linda, Kashiwagi, Masahide, Murphy, Gillian, Nagase, Hideaki, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Matthews, R. James, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2019. ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. Scientific Reports 9 , 5487. 10.1038/s41598-019-41811-z
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Galloway, Sarah A. E., Dolton, Garry, Attaf, Meriem, Wall, Aaron, Fuller, Anna, Rius, Cristina, Bianchi, Valentina, Theaker, Sarah, Lloyd, Angharad, Caillaud, Marine E., Svane, Inge Marie, Donia, Marco, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2019. Peptide super-agonist enhances T-cell responses to melanoma. Frontiers in Immunology 10 , 319. 10.3389/fimmu.2019.00319
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Yeo, Lorraine, Woodwyk, Alyssa, Sood, Sanjana, Lorenc, Anna, Eichmann, Martin, Pujol-Autonell, Irma, Melchiotti, Rosella, Skowera, Ania, Fidanis, Efthymios, Dolton, Garry M., Tungatt, Katie, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Heck, Susanne, Saxena, Alka, Beam, Craig A. and Peakman, Mark 2018. Autoreactive T effector memory differentiation mirrors b cell function in type 1 diabetes. Journal of Clinical Investigation 128 (8) , pp. 3460-3474. 10.1172/JCI120555
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Zhao, Xiang, Sankaran, Shvetha, Yap, Jiawei, Too, Chien Tei, Ho, Zi Zong, Dolton, Garry, Legut, Mateusz, Ren, Ee Chee, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Bertoletti, Antonio, MacAry, Paul A., Brzostek, Joanna and Gascoigne, Nicholas R. J. 2018. Nonstimulatory peptide?MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nature Communications 9 , 2716. 10.1038/s41467-018-05288-0
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Dolton, Garry, Zervoudi, Efthalia, Rius Rafael, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Wall, Aaron, Thomas, Hannah L., Fuller, Anna, Yeo, Lorraine, Legut, Mateusz, Wheeler, Sophie, Attaf, Meriem, Chudakov, Dmitriy M., Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609, Peakman, Mark and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2018. Optimized peptide-MHC multimer protocols for detection and isolation of autoimmune T-cells. Frontiers in Immunology 9 , 1378. 10.3389/fimmu.2018.01378
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Tungatt, Katie, Dolton, Garry, Morgan, Sophie B., Attaf, Meriem, Fuller, Anna, Whalley, Thomas, Hemmink, Johanneke D., Porter, Emily, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Montoya, Maria, Hammond, John A., Miles, John J., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Townsend, Alain, Bailey, Mick, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Charleston, Bryan, Tchilian, Elma and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2018. Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens 14 (5) , e1007017. 10.1371/journal.ppat.1007017
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Miles, John J., Tan, Mai Ping, Dolton, Garry, Edwards, Emily S. J. ORCID: https://orcid.org/0000-0002-0240-4370, Galloway, Sarah A. E., Laugel, Bruno, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Makinde, Julia, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Matthews, Katherine K., Watkins, Thomas S., Tungatt, Katie, Wong, Yide, Lee, Han Siean, Clark, Richard J., Pentier, Johanne M., Attaf, Meriem, Lissina, Anya, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Gras, Stephanie, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Burrows, Scott R., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128 (4) , pp. 1569-1580. 10.1172/JCI91512
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Rius, Cristina, Attaf, Meriem, Tungatt, Katie, Bianchi, Valentina, Legut, Mateusz, Bovay, Amandine, Donia, Marco, Straten, Per thor, Peakman, Mark, Svane, Inge Marie, Ott, Sascha, Connor, Tom ORCID: https://orcid.org/0000-0003-2394-6504, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Dolton, Garry and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2018. Peptide-MHC class 1 tetramers can fail to detect relevant functional T cell clonotypes and underestimate antigen-reactive T cell populations. Journal of Immunology 200 (7) , pp. 2263-2279. 10.4049/jimmunol.1700242
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Bovay, Amandine, Zoete, Vincent, Dolton, Garry, Bulek, Anna M., Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Fuller, Anna, Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Michielin, Olivier, Speiser, Daniel E., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Fuertes Marraco, Silvia A. 2018. T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus. European Journal of Immunology 48 (2) , pp. 258-272. 10.1002/eji.201747082
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Legut, Mateusz, Dolton, Garry, Mian, Afsar, Ottmann, Oliver ORCID: https://orcid.org/0000-0001-9559-1330 and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135 2018. CRISPR-mediated TCR replacement generates superior anticancer transgenic T-cells. Blood 131 (3) , pp. 311-322. 10.1182/blood-2017-05-787598
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Shugay, M., Bagaev, D. V., Zvyagin, I. V., Vroomans, R. M., Crawford, J. C., Dolton, Garry M., Komech, Ekaterina A., Sycheva, Anastasiya L., Koneva, Anna E., Egorov, Evgeniy S., Eliseev, Alexey V., Van Dyk, E., Dash, P., Attaf, Meriem, Ruis, Cristina, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Matthews, Katherine K., Clemens, Ella B., Douek, Daniel C., Luciani, Fabio, Van Baarle, D., Kedzierska, Katherine, Kesmir, Can, Thomas, Paul G., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Chudakov, Dimitry M. 2018. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research 46 (D1) , D419-D427. 10.1093/nar/gkx760
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Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Fuller, Anna, Dolton, Garry, Zervoudi, Efthalia, Legut, Mateusz, Miles, Kim, Blanchfield, Lori, Madura, Florian, Holland, Christopher J., Bulek, Anna M., Bridgeman, John S., Miles, John J., Schauenburg, Andrea J. A., Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Evavold, Brian D., Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2017. Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope. Frontiers in Immunology 8 , 1503. 10.3389/fimmu.2017.01503
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Jones, Nicholas, Cronin, James G., Dolton, Garry, Panetti, Silvia, Schauenburg, Andrea, Galloway, Sarah A. E., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Thornton, Catherine A. and Francis, Nigel J. ORCID: https://orcid.org/0000-0002-4706-4795 2017. Metabolic adaptation of human CD4+ and CD8+ T-Cells to T-Cell receptor-mediated stimulation. Frontiers in Immunology 8 , 1516. 10.3389/fimmu.2017.01516
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Donia, Marco, Kjeldsen, Julie Westerlin, Andersen, Rikke, Wulff Westergaard, Marie Christine, Bianchi, Valentina, Legut, Mateusz, Attaf, Meriem, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Ott, Sascha, Dolton, Garry, Lyngaa, Rikke, Hadrup, Sine Reker, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Svane, Inge Marie 2017. PD-1+ polyfunctional T cells dominate the periphery after tumour-infiltrating lymphocyte therapy for cancer. Clinical Cancer Research 23 (19) , pp. 5779-5788. 10.1158/1078-0432.CCR-16-1692
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Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, van den Berg, Hugo A., Lloyd, Angharad, Crowther, Michael D., Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Ekeruche-Makinde, Julia, Miles, John J., Bulek, Anna M., Dolton, Garry, Schauenburg, Andrea J., Wall, Aaron, Fuller, Anna, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Laugel, Bruno, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry 292 (3) , pp. 802-813. 10.1074/jbc.M116.741603
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Tan, M., Dolton, Garry Michael, Gerry, Andrew B., Brewer, Joanna E., Bennett, Alan D., Pumphrey, Nick, Jakobsen, Bent K. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2017. HLA class I-redirected anti-tumour CD4+T-cells require a higher TCR binding affinity for optimal activity than CD8+T-cells. Clinical and Experimental Immunology 187 (1) , pp. 124-137. 10.1111/cei.12828
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Watson, H. Angharad, Dolton, Garry Michael, Ohme, Julia, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Vigar, Miriam, Wehenkel, Sophie, Hindley, James, Mohammed, Rebar, Miners, Kelly, Luckwell, Rhys A, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Matthews, R James and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2016. Purity of transferred CD8+ T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1. Immunology and Cell Biology 94 (8) 10.1038/icb.2016.45
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Pageon, Sophie V., Tabarin, Thibault, Yamamoto, Yui, Ma, Yuanqing, Bridgeman, John S, Cohnen, André, Benzing, Carola, Gao, Yijun, Crowther, Michael D, Tungatt, Katie, Dolton, Garry, Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135, Price, David A ORCID: https://orcid.org/0000-0001-9416-2737, Acuto, Oreste, Parton, Robert G., Gooding, J. Justin, Rossy, Jérémie, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522 and Gaus, Katharina 2016. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proceedings of the National Academy of Sciences 113 (37) , E5454-E5463. 10.1073/pnas.1607436113
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Laugel, Bruno, Lloyd, Angharad, Meermeier, Erin W., Crowther, Michael D., Connor, Thomas ORCID: https://orcid.org/0000-0003-2394-6504, Dolton, Garry Michael, Miles, John James, Burrows, Scott R., Gold, Marielle C., Lewinsohn, David M. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2016. Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system: tools to study microbial antigen processing and presentation to human MR1-restricted T cells. Journal of Immunology 197 (3) , pp. 971-982. 10.4049/jimmunol.1501402
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Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Liu, Jie, Brown, Paul E., Miles, John J., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Llewellyn-Lacey, Sian, Dolton, Garry, Ekeruche-Makinde, Julia, Lissina, Anya, Schauenburg, Andrea J., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Burrows, Scott R., Roederer, Mario, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and van den Berg, Hugo A. 2016. Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology 94 (6) , pp. 573-582. 10.1038/icb.2016.12
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Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Bulek, Anna M., Dolton, Garry, Schauenberg, Andrea J., Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Rittase, William, Trimby, Andrew, Jothikumar, Prithiviraj, Fuller, Anna, Skowera, Ania, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Zhu, Cheng, Miles, John J., Peakman, Mark, Wooldridge, Linda, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2016. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation 126 (6) , pp. 2191-2204. 10.1172/JCI85679
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Caucheteux, Stephan M., Mitchell, John P., Ivory, Matthew O. ORCID: https://orcid.org/0000-0002-8736-395X, Hirosue, Sachiko, Hakobyan, Svetlana, Dolton, Garry, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Kan-Mitchell, June, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Nestle, Frank, Moris, Arnaud, Karoo, Richard O., Birchall, James C. ORCID: https://orcid.org/0000-0001-8521-6924, Swartz, Melody A., Hubbel, Jeffrey A., Blanchet, Fabien P. and Piguet, Vincent 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136 (6) , pp. 1172-1181. 10.1016/j.jid.2016.01.033
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Bianchi, Valentina, Bulek, Anna, Fuller, Anna, Lloyd, Angharad, Attaf, Meriem, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Dolton, Garry, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 2016. A molecular switch abrogates glycoprotein 100 (gp100) T-cell Receptor (TCR) targeting of a human melanoma antigen. Journal of Biological Chemistry 291 (17) , pp. 8951-8959. 10.1074/jbc.M115.707414
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Theaker, Sarah M., Rius Rafael, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Greenshields-Watson, Alexander, Lloyd, Angharad, Trimby, Andrew R., Fuller, Anna, Miles, John James, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Peakman, Mark, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Dolton, Garry Michael 2016. T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Journal of Immunological Methods 430 , pp. 43-50. 10.1016/j.jim.2016.01.014
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Holland, Christopher J., Dolton, Garry M., Scurr, Martin ORCID: https://orcid.org/0000-0002-4120-0688, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Schauenburg, Andrea J., Miners, Kelly, Madura, Florian, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396 and Godkin, Andrew J. ORCID: https://orcid.org/0000-0002-1910-7567 2015. Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers. Journal of Immunology 195 (12) , pp. 5827-5836. 10.4049/jimmunol.1402787
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Dolton, Garry Michael, Tungatt, Katie, Lloyd, Angharad, Bianchi, Valentina, Theaker, Sarah M., Trimby, Andrew R., Holland, Christopher J., Donia, Marco, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Straten, Per Thor, Peakman, Mark, Svane, Inge Marie and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2015. More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers. Immunology 146 (1) , pp. 11-22. 10.1111/imm.12499

Neller, Michelle A., Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Matthews, Katherine K., Gostick, Emma, Pentier, Johanne, Dolton, Garry Michael, Schauenburg, Andrea J. A., Koning, Dan, Fontaine Costa, Ana Isabel C. A., Watkins, Thomas S., Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly Louise, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Wooldridge, Linda, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, van Baarle, Debbie, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Burrows, Scott R., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Miles, John James 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93 , pp. 625-633. 10.1038/icb.2015.17
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Skowera, Ania, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Dolton, Garry Michael, Matthews, Katherine K., Gostick, Emma, Kronenberg-Versteeg, Deborah, Eichmann, Martin, Knight, Robin R., Heck, Susanne, Powrie, Jake, Bingley, Polly J., Dayan, Colin Mark ORCID: https://orcid.org/0000-0002-6557-3462, Miles, John J., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Peakman, Mark 2015. β-Cell-specific CD8 T Cell phenotype in Type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64 (3) , pp. 916-925. 10.2337/db14-0332
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Tungatt, Katie, Bianchi, Valentina, Crowther, Michael D., Powell, Wendy ORCID: https://orcid.org/0000-0002-4670-1406, Schauenburg, Andrea J. A., Trimby, Andrew R., Donia, M., Miles, John James, Holland, Christopher J., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Peakman, M., Straten, P. T., Svane, I. M., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Dolton, Garry Michael 2015. Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs. Journal of Immunology 194 (1) , pp. 463-474. 10.4049/jimmunol.1401785
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Knight, R. R., Dolton, Garry Michael, Kronenberg-Versteeg, D., Eichmann, M., Zhao, M., Huang, G. C., Beck, Konrad ORCID: https://orcid.org/0000-0001-5098-9484, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Skowera, A. and Peakman, M. 2015. A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells. Clinical and Experimental Immunology 179 (1) , pp. 100-107. 10.1111/cei.12436

Dolton, Garry Michael, Lissina, A., Skowera, A., Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Tungatt, Katie, Jones, Emma, Kronenberg-Versteeg, D., Akpovwa, Hephzibah, Pentier, Johanne, Holland, C. J., Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Neller, M. A., Miles, John James, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Peakman, M. and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2014. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology 177 (1) , pp. 47-63. 10.1111/cei.12339
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Stacey, Maria A., Marsden, Morgan, Pham N., Tu Anh, Clare, Simon, Dolton, Garry, Stack, Gabrielle, Jones, Emma, Klenerman, Paul, Gallimore, Awen M. ORCID: https://orcid.org/0000-0001-6675-7004, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Snelgrove, Robert J., Lawley, Trevor D., Dougan, Gordon, Benedict, Chris A., Jones, Simon A., Wilkinson, Gavin W. G. ORCID: https://orcid.org/0000-0002-5623-0126 and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2014. Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell Host and Microbe 15 (4) , pp. 471-483. 10.1016/j.chom.2014.03.003
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Eukeruche-Makinde, Julia, Miles, John J., Van Den Berg, Hugo A., Skowera, Ania, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Dolton, Garry Michael, Schauenburg, Andrea, Tan, Mai Ping, Pentier, Johanne, Llewellyn-Lacey, Sian, Miles, Kim M., Bulek, Anna, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Dockree, Tamsin, Trimby, Andrew R., Bailey, Mick, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Peakman, Mark, Burrows, Scott, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Wooldridge, Linda 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121 (7) , pp. 1112-1123. 10.1182/blood-2012-06-437202

Ekeruche, Julia, Miles, John James, van den Berg, Hugo A., Skowera, Ania, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Dolton, Garry Michael, Schauenburg, Andrea J. A., Tan, Mai Ping, Pentier, Johanne, Llewellyn-Lacey, Sian, Miles, Kim Michelle, Bulek, Anna Marta, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Williams, Tamsin, Trimby, Andrew R., Bailey, Mick, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Peakman, Mark, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Burrows, Scott R., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Wooldridge, Linda 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121 (7) , pp. 1112-1123. 10.1182/blood-2012-06-437202

Ekeruche-Makinde, Julia, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Edwards, Emily S. J. ORCID: https://orcid.org/0000-0002-0240-4370, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miles, John J., Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry M., Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409
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Ekeruche, Julia, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Edwards, Emily S. J. ORCID: https://orcid.org/0000-0002-0240-4370, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Miles, John James, Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry Michael, Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Wooldridge, Linda and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409

Bulek, Anna, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Skowera, Ania, Dolton, Garry, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Drijfhout, Jan W, Knight, Robin R, Huang, Guo C, Lissin, Nikolai, Molloy, Peter E, Wooldridge, Linda, Jakobsen, Bent K, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Peakman, Mark, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13 (3) , pp. 283-289. 10.1038/ni.2206

Bulek, Anna Marta, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Skowera, Ania, Dolton, Garry Michael, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John James, Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Drijfhout, Jan W., Knight, Robin R., Huang, Guo C., Lissin, Nikolai, Molloy, Peter E., Wooldridge, Linda, Jakobsen, Bent K., Rossjohn, Jamie, Peakman, Mark, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13 (3) , pp. 283-289. 10.1038/ni.2206

Wooldridge, Linda, Ekeruche, Julia, van den Berg, Hugo A., Skowera, Anna, Miles, John James, Tan, Mai Ping, Dolton, Garry Michael, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Llewellyn-Lacey, Sian, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Peakman, Mark and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2012. A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry 287 (2) , pp. 1168-1177. 10.1074/jbc.M111.289488
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Nunes, Claudia Trindade, Miners, Kelly Louise, Dolton, Garry Michael, Pepper, Christopher John, Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, Mason, Malcolm David ORCID: https://orcid.org/0000-0003-1505-2869 and Man, Stephen Tzekwung ORCID: https://orcid.org/0000-0001-9103-1686 2011. A novel tumor antigen derived from enhanced degradation of Bax protein in human cancers. Cancer Research 71 (16) , pp. 5435-5444. 10.1158/0008-5472.CAN-11-0393

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Ekeruche, Julia, Miles, John James, Edwards, Emily ORCID: https://orcid.org/0000-0002-0240-4370, Dolton, Garry Michael, Williams, Tamsin, Schauenburg, Andrea J. A., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Lauder, Sarah Nicol, Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Burrows, Scott R., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Wooldridge, Linda 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2) , pp. 654-663. 10.4049/jimmunol.1003941

Cuff, Simone ORCID: https://orcid.org/0000-0002-0546-3579, Dolton, Garry Michael, Matthews, Reginald James and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2010. Antigen specificity determines the pro- or antitumoral nature of CD8+ T cells. The Journal of Immunology 184 (2) , pp. 607-614. 10.4049/jimmunol.0804089

Miles, John James, Bulek, Anna Marta, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Gostick, Emma, Schauenburg, Andrea J. A., Dolton, Garry Michael, Venturi, Vanessa, Davenport, Miles P., Tan, Mai Ping, Burrows, Scott R., Wooldridge, Linda, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 2010. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathogens 6 (11) , e1001198. 10.1371/journal.ppat.1001198
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Dolton, Garry Michael 2008. Role of SHP-1 in in vivo CD8+ T cell responses to antigenic stimulation. PhD Thesis, Cardiff University.
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Sathish, Jean G., Dolton, Garry Michael, Leroy, F. G. and Matthews, Reginald James 2007. Loss of Src homology region 2 domain-containing protein tyrosine phosphatase-1 increases CD8+ T cell-APC conjugate formation and is associated with enhanced in vivo CTL function. Journal of immunology 178 , pp. 330-337.

This list was generated on Mon Nov 3 11:52:40 2025 GMT.


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