Associations between dog breed and clinical features of mammary epithelial neoplasia in bitches: an epidemiological study of submissions to a single diagnostic pathology centre between 2008-2021

Edmunds, Grace, Beck, Sam, Umakant Kale, Kedar, Spasic, Irena ORCID: https://orcid.org/0000-0002-8132-3885, O'Neill, Dan, Brodbelt, David and Smalley, Matthew J ORCID: https://orcid.org/0000-0001-9540-1146 2023. Associations between dog breed and clinical features of mammary epithelial neoplasia in bitches: an epidemiological study of submissions to a single diagnostic pathology centre between 2008-2021. Journal of Mammary Gland Biology and Neoplasia 28 (6) 10.1007/s10911-023-09531-3

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Abstract

Mammary cancer is one of the most common neoplasms of dogs, primarily bitches. While studies have been carried out identifying differing risk of mammary neoplasia in different dog breeds, few studies have reported associations between dog breeds and clinical features such as number of neoplastic lesions found in an individual case or the likelihood of lesions being benign or malignant. Such epidemiological studies are essential as a foundation for exploring potential genetic drivers of mammary tumour behaviour. Here, we have examined associations between breed, age and neuter status and the odds of a diagnosis of a mammary epithelial-origin neoplastic lesion (as opposed to any other histopathological diagnosis from a biopsied lesion) as well as the odds of a bitch presenting with either a single mammary lesion or multiple lesions, and the odds that those lesions are benign or malignant. The study population consisted of 129,258 samples from bitches, including 13,401 mammary epithelial neoplasms, submitted for histological assessment to a single histopathology laboratory between 2008 and 2021.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Computer Science & Informatics Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
ISSN:	1573-7039
Date of First Compliant Deposit:	27 February 2023
Date of Acceptance:	25 February 2023
Last Modified:	24 Mar 2023 10:24
URI:	https://orca.cardiff.ac.uk/id/eprint/157371

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