Surface acoustic wave‐enhanced multi‐view acoustofluidic rotation cytometry (MARC) for pre‐cytopathological screening

Zhang, Xiaoyan, Dumčius, Povilas, Mikhaylov, Roman, Qi, Jiangfa, Stringer, Mercedes, Sun, Chao, Nguyen, Van Dien, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Sun, Xianfang ORCID: https://orcid.org/0000-0002-6114-0766, Liang, Dongfang, Liu, Dongge, Yan, Bing, Feng, Xi, Mei, Changjun, Xu, Cong, Feng, Mingqian, Fu, Yongqing, Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Zhi, Ruicong, Tian, Liangfei, Dong, Zhiqiang and Yang, Xin ORCID: https://orcid.org/0000-0002-8429-7598 2024. Surface acoustic wave‐enhanced multi‐view acoustofluidic rotation cytometry (MARC) for pre‐cytopathological screening. Advanced Science 11 (39) , 2403574. 10.1002/advs.202403574

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Abstract

Cytopathology, crucial in disease diagnosis, commonly uses microscopic slides to scrutinize cellular abnormalities. However, processing high volumes of samples often results in numerous negative diagnoses, consuming significant time and resources in healthcare. To address this challenge, a surface acoustic wave‐enhanced multi‐view acoustofluidic rotation cytometry (MARC) technique is developed for pre‐cytopathological screening. MARC enhances cellular morphology analysis through comprehensive and multi‐angle observations and amplifies subtle cell differences, particularly in the nuclear‐to‐cytoplasmic ratio, across various cell types and between cancerous and normal tissue cells. By prioritizing MARC‐screened positive cases, this approach can potentially streamline traditional cytopathology, reducing the workload and resources spent on negative diagnoses. This significant advancement enhances overall diagnostic efficiency, offering a transformative vision for cytopathological screening.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Engineering Medicine Computer Science & Informatics
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/
Publisher:	Wiley Open Access
ISSN:	2198-3844
Date of First Compliant Deposit:	14 August 2024
Date of Acceptance:	20 July 2024
Last Modified:	04 Nov 2024 14:46
URI:	https://orca.cardiff.ac.uk/id/eprint/171392

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